Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   GFB63_RS04640 Genome accession   NZ_CP045596
Coordinates   898315..898503 (+) Length   62 a.a.
NCBI ID   WP_193838416.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain TK-P3A     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 871092..898503 898315..898503 within 0
IScluster/Tn 898875..899215 898315..898503 flank 372


Gene organization within MGE regions


Location: 871092..899215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GFB63_RS04520 (GFB63_04640) - 871092..874817 (+) 3726 WP_100262639.1 phosphoribosylformylglycinamidine synthase -
  GFB63_RS04525 (GFB63_04645) purF 874986..876425 (+) 1440 WP_084828407.1 amidophosphoribosyltransferase -
  GFB63_RS04530 (GFB63_04650) purM 876596..877618 (+) 1023 WP_084828408.1 phosphoribosylformylglycinamidine cyclo-ligase -
  GFB63_RS04535 (GFB63_04655) purN 877618..878172 (+) 555 WP_084828409.1 phosphoribosylglycinamide formyltransferase -
  GFB63_RS04540 (GFB63_04660) purH 878241..879788 (+) 1548 WP_193838405.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  GFB63_RS04545 (GFB63_04665) - 879960..881082 (+) 1123 Protein_883 IS3 family transposase -
  GFB63_RS04550 (GFB63_04670) - 881189..882028 (-) 840 WP_193838406.1 CHAP domain-containing protein -
  GFB63_RS04555 (GFB63_04675) purD 882336..883598 (+) 1263 WP_193838407.1 phosphoribosylamine--glycine ligase -
  GFB63_RS04560 (GFB63_04680) purE 883944..884432 (+) 489 WP_002948169.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  GFB63_RS04565 (GFB63_04685) purK 884419..885510 (+) 1092 WP_002949035.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  GFB63_RS10545 - 885511..886020 (+) 510 Protein_888 ketopantoate reductase family protein -
  GFB63_RS04575 (GFB63_04695) purB 886134..887432 (+) 1299 WP_037599433.1 adenylosuccinate lyase -
  GFB63_RS04580 (GFB63_04700) argS 888295..889986 (-) 1692 WP_193838408.1 arginine--tRNA ligase -
  GFB63_RS04585 (GFB63_04705) - 890193..891359 (-) 1167 WP_193838409.1 site-specific integrase -
  GFB63_RS04590 (GFB63_04710) - 891734..892300 (-) 567 WP_193838410.1 helix-turn-helix domain-containing protein -
  GFB63_RS04595 (GFB63_04715) - 892459..892656 (+) 198 WP_101361301.1 helix-turn-helix transcriptional regulator -
  GFB63_RS04600 (GFB63_04720) - 892880..893173 (+) 294 WP_193838411.1 hypothetical protein -
  GFB63_RS04605 (GFB63_04725) - 893177..893371 (+) 195 WP_193838412.1 hypothetical protein -
  GFB63_RS04610 (GFB63_04730) - 893385..893621 (+) 237 WP_193838413.1 hypothetical protein -
  GFB63_RS04615 (GFB63_04740) - 893950..894223 (+) 274 Protein_897 MerR family transcriptional regulator -
  GFB63_RS04620 (GFB63_04745) - 894239..895099 (+) 861 WP_193838414.1 primase alpha helix C-terminal domain-containing protein -
  GFB63_RS04625 (GFB63_04750) - 895089..896597 (+) 1509 WP_409350143.1 phage/plasmid primase, P4 family -
  GFB63_RS04630 (GFB63_04755) - 896894..897079 (+) 186 WP_084829533.1 hypothetical protein -
  GFB63_RS04635 (GFB63_04760) - 897096..897371 (+) 276 WP_193838415.1 hypothetical protein -
  GFB63_RS04640 (GFB63_04770) prx 898315..898503 (+) 189 WP_193838416.1 hypothetical protein Regulator
  GFB63_RS04645 (GFB63_04775) - 898770..899096 (-) 327 Protein_903 transposase -
  GFB63_RS11135 - 899078..899215 (-) 138 WP_002948564.1 hypothetical protein -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7093.05 Da        Isoelectric Point: 4.4665

>NTDB_id=395468 GFB63_RS04640 WP_193838416.1 898315..898503(+) (prx) [Streptococcus thermophilus strain TK-P3A]
MLTYDEFKEAMDKGFIKGDTVQIVRKNGKIHDYVLDGERVDPHEILSLEKVSDIIKELGEGE

Nucleotide


Download         Length: 189 bp        

>NTDB_id=395468 GFB63_RS04640 WP_193838416.1 898315..898503(+) (prx) [Streptococcus thermophilus strain TK-P3A]
ATGCTAACCTATGATGAATTTAAAGAGGCTATGGACAAGGGTTTTATTAAAGGTGATACTGTCCAGATTGTCCGAAAGAA
TGGTAAGATCCATGACTACGTTTTAGATGGTGAACGAGTTGATCCACACGAAATATTGAGCTTAGAAAAGGTATCGGATA
TAATAAAGGAGCTAGGCGAGGGCGAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

58.621

93.548

0.548
  prx Streptococcus pyogenes MGAS8232

57.627

95.161

0.548
  prx Streptococcus pyogenes MGAS315

57.627

95.161

0.548
  prx Streptococcus pyogenes MGAS315

56.897

93.548

0.532
  prx Streptococcus pyogenes MGAS315

72.093

69.355

0.5
  prx Streptococcus pyogenes MGAS315

68.182

70.968

0.484
  prx Streptococcus pyogenes MGAS315

75

64.516

0.484

Multiple sequence alignment