Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   LPB220_RS04610 Genome accession   NZ_CP044230
Coordinates   875829..876509 (+) Length   226 a.a.
NCBI ID   WP_049486302.1    Uniprot ID   A0A6A8V6P6
Organism   Streptococcus sp. LPB0220     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 870829..881509
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LPB220_RS04585 (LPB220_04590) - 871764..872474 (-) 711 WP_150905814.1 LytR/AlgR family response regulator transcription factor -
  LPB220_RS04590 (LPB220_04595) - 872581..873537 (+) 957 WP_150906793.1 ABC transporter ATP-binding protein -
  LPB220_RS04595 (LPB220_04600) - 873539..874261 (+) 723 WP_150905816.1 ABC transporter permease -
  LPB220_RS04600 (LPB220_04605) - 874414..874947 (-) 534 WP_021152981.1 biotin transporter BioY -
  LPB220_RS04605 (LPB220_04610) - 875154..875693 (+) 540 WP_150905818.1 hypothetical protein -
  LPB220_RS04610 (LPB220_04615) ciaR 875829..876509 (+) 681 WP_049486302.1 response regulator transcription factor Regulator
  LPB220_RS04615 (LPB220_04620) ciaH 876493..877854 (+) 1362 WP_150905820.1 sensor histidine kinase Regulator
  LPB220_RS04620 (LPB220_04625) - 877884..878264 (+) 381 WP_003006623.1 VOC family protein -
  LPB220_RS04625 (LPB220_04630) - 878523..879905 (+) 1383 WP_150905822.1 polysaccharide deacetylase family protein -
  LPB220_RS04630 (LPB220_04635) - 879948..881033 (-) 1086 WP_150905824.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25767.46 Da        Isoelectric Point: 4.3186

>NTDB_id=388994 LPB220_RS04610 WP_049486302.1 875829..876509(+) (ciaR) [Streptococcus sp. LPB0220]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDDKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANQN

Nucleotide


Download         Length: 681 bp        

>NTDB_id=388994 LPB220_RS04610 WP_049486302.1 875829..876509(+) (ciaR) [Streptococcus sp. LPB0220]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTATCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGACGT
TATGCAGGTCTTTGACGGAGAAGAAGGTCTTTATGAAGCAGAAAGTGGCATCTATGATTTGATTTTGCTGGACCTCATGC
TTCCTGAAAAAGACGGTTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTTTAATCATGACAGCT
AAAGAAAGCCTGGATGACAAGGGACACGGCTTTGAGCTAGGGGCAGACGATTACCTCACCAAGCCTTTCTACCTGGAAGA
GCTTAAGATGCGGATTCAAGCCCTCTTGAAGCGCTCAGGAAAGGTCAATGAAAATACCCTTAATTATGGCAATTTGAAGG
TCAACTTATCTACCAATTCGACTTACGTGGACGATAAGGAAGTGGAACTTCTTGGGAAGGAATTTGATCTCTTGGTCTAC
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAGACACAGATTTTCGATCGCCTTTGGGGCTTTGACAGTGATACGACCAT
CTCTGTTGTTGAAGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACCGATTTCGTTGAGAGCTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6A8V6P6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae D39

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae R6

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae TIGR4

90.625

99.115

0.898
  ciaR Streptococcus mutans UA159

87.946

99.115

0.872
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.445

100

0.376
  vicR Streptococcus mutans UA159

36.052

100

0.372
  micA Streptococcus pneumoniae Cp1015

34.746

100

0.363

Multiple sequence alignment