Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   LPB220_RS04615 Genome accession   NZ_CP044230
Coordinates   876493..877854 (+) Length   453 a.a.
NCBI ID   WP_150905820.1    Uniprot ID   A0A5J6LN89
Organism   Streptococcus sp. LPB0220     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 871493..882854
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LPB220_RS04585 (LPB220_04590) - 871764..872474 (-) 711 WP_150905814.1 LytR/AlgR family response regulator transcription factor -
  LPB220_RS04590 (LPB220_04595) - 872581..873537 (+) 957 WP_150906793.1 ABC transporter ATP-binding protein -
  LPB220_RS04595 (LPB220_04600) - 873539..874261 (+) 723 WP_150905816.1 ABC transporter permease -
  LPB220_RS04600 (LPB220_04605) - 874414..874947 (-) 534 WP_021152981.1 biotin transporter BioY -
  LPB220_RS04605 (LPB220_04610) - 875154..875693 (+) 540 WP_150905818.1 hypothetical protein -
  LPB220_RS04610 (LPB220_04615) ciaR 875829..876509 (+) 681 WP_049486302.1 response regulator transcription factor Regulator
  LPB220_RS04615 (LPB220_04620) ciaH 876493..877854 (+) 1362 WP_150905820.1 sensor histidine kinase Regulator
  LPB220_RS04620 (LPB220_04625) - 877884..878264 (+) 381 WP_003006623.1 VOC family protein -
  LPB220_RS04625 (LPB220_04630) - 878523..879905 (+) 1383 WP_150905822.1 polysaccharide deacetylase family protein -
  LPB220_RS04630 (LPB220_04635) - 879948..881033 (-) 1086 WP_150905824.1 DEAD/DEAH box helicase -
  LPB220_RS04635 (LPB220_04640) - 881030..882010 (-) 981 WP_150905826.1 Gfo/Idh/MocA family protein -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 51958.32 Da        Isoelectric Point: 6.2114

>NTDB_id=388995 LPB220_RS04615 WP_150905820.1 876493..877854(+) (ciaH) [Streptococcus sp. LPB0220]
MLTRIKKTVGEDDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTTVDENLKTLSQDPYSLVAIAYRDQRQSNTKGDDND
HEMMIPDHDKSEPKGDVTSNTTVVLLNKKYENLTTGNGFLNFKTVTFGRKLLNKVSQLQITNSYGKKESYRAYMAELSLS
DDESDSDIKYAVVMTNISQLEQTSEEHESQIALVMICFWGISLFASLFLARLSVKPLLESMQKQKAFVENASHELRTPLA
VLQNRLETLFRKPEATIMESSENIASSLDEVRNMKLLTTNLLNIARRDDGLKPEMEDIEPSFFDQTFSNFEIIAEENDKL
FRGDNQVDKVICSDRTLLKQLMTILYDNALKYTDEDGEIQFEVQLKDKNLLLRVLDNGPGIRDEDKKRIFDRFYRVDKAR
TRQKGGFGLGLSLAKQIVEAFKGTIQVKDNKPKGTIFEVKLSIKTESRKKNRS

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=388995 LPB220_RS04615 WP_150905820.1 876493..877854(+) (ciaH) [Streptococcus sp. LPB0220]
ATGCTAACCAGAATTAAGAAAACTGTCGGAGAAGATGATTTTTCCTACTTCATCCGATATTTTGGGCTCTTTACTTTGAT
ATTCTCAGCCATGACCCTGATTATCATCCAGGTCATGCGCTCGAGTCTCTATACAACGGTCGATGAAAACCTCAAGACTC
TCAGTCAGGATCCATACTCACTTGTAGCGATTGCTTATCGAGACCAGCGACAGTCAAATACCAAAGGAGATGATAATGAT
CATGAGATGATGATCCCAGATCATGATAAATCAGAACCTAAAGGGGATGTCACATCCAATACCACTGTTGTTTTGCTCAA
TAAAAAATATGAAAACTTGACAACCGGTAATGGGTTTTTAAACTTCAAAACGGTGACGTTTGGTCGAAAGCTCCTCAACA
AGGTTTCCCAGCTTCAAATTACAAATAGCTATGGGAAAAAAGAAAGTTACCGGGCTTATATGGCAGAGTTGAGTTTATCT
GATGATGAAAGTGATAGTGATATCAAGTATGCGGTTGTCATGACCAATATCAGTCAGCTAGAGCAGACCAGTGAAGAGCA
CGAAAGCCAAATCGCCCTTGTCATGATCTGCTTCTGGGGAATCTCTTTATTCGCTAGTCTCTTCTTAGCACGTCTCAGCG
TCAAGCCCCTTCTTGAGAGTATGCAAAAGCAAAAGGCTTTCGTGGAAAATGCTTCCCATGAGTTGCGGACGCCTTTAGCA
GTTCTGCAAAATCGCCTCGAAACGCTTTTTAGAAAGCCTGAAGCGACCATTATGGAATCGAGTGAGAATATTGCATCCAG
CTTGGATGAAGTTCGAAATATGAAGCTCTTGACTACCAACCTTCTTAACATTGCCCGAAGAGATGACGGCTTGAAGCCGG
AGATGGAAGATATCGAACCAAGCTTTTTCGATCAGACCTTCTCGAATTTTGAGATCATTGCGGAAGAAAATGATAAACTC
TTCCGAGGAGACAATCAGGTGGACAAAGTCATTTGTTCTGATAGAACGCTCCTCAAGCAATTGATGACCATTCTCTATGA
CAATGCCTTGAAATATACCGATGAAGATGGCGAGATCCAGTTTGAAGTCCAGTTGAAGGATAAAAATCTTCTTTTGAGAG
TACTGGATAATGGTCCAGGGATTCGAGATGAGGATAAGAAACGGATTTTTGATCGTTTTTACCGGGTCGACAAGGCCAGA
ACCCGTCAGAAAGGTGGATTTGGTTTGGGGTTATCCCTCGCTAAGCAGATTGTAGAAGCCTTTAAAGGGACCATTCAAGT
CAAAGATAATAAACCAAAAGGGACCATCTTTGAAGTGAAATTATCCATTAAGACGGAAAGTCGTAAAAAAAATCGTTCAT
AA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(225-290)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(334-442)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5J6LN89

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

60.444

99.338

0.6
  ciaH Streptococcus pneumoniae D39

60.444

99.338

0.6
  ciaH Streptococcus pneumoniae R6

60.444

99.338

0.6
  ciaH Streptococcus pneumoniae TIGR4

60.444

99.338

0.6
  ciaH Streptococcus mutans UA159

50.113

97.351

0.488

Multiple sequence alignment