Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   F1537_RS06570 Genome accession   NZ_CP043770
Coordinates   1276000..1277337 (-) Length   445 a.a.
NCBI ID   WP_013526477.1    Uniprot ID   -
Organism   Haemophilus influenzae biotype aegyptius strain HE7/F1946     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1271000..1282337
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F1537_RS06545 (F1537_06555) - 1272730..1273002 (-) 273 WP_013526482.1 HU family DNA-binding protein -
  F1537_RS06550 (F1537_06560) - 1273142..1273732 (-) 591 WP_013526481.1 YjaG family protein -
  F1537_RS06555 (F1537_06565) nudC 1273768..1274562 (-) 795 WP_013526480.1 NAD(+) diphosphatase -
  F1537_RS06560 (F1537_06570) nfuA 1274629..1275225 (-) 597 WP_013526479.1 Fe-S biogenesis protein NfuA -
  F1537_RS06565 (F1537_06575) - 1275301..1275987 (-) 687 WP_013526478.1 ComF family protein -
  F1537_RS06570 (F1537_06580) comE 1276000..1277337 (-) 1338 WP_013526477.1 type IV pilus secretin PilQ family protein Machinery gene
  F1537_RS06575 (F1537_06585) comD 1277347..1277760 (-) 414 WP_013526476.1 pilus assembly protein PilP Machinery gene
  F1537_RS06580 (F1537_06590) comC 1277757..1278278 (-) 522 WP_041174979.1 competence protein ComC Machinery gene
  F1537_RS06585 (F1537_06595) comB 1278275..1278781 (-) 507 WP_013526474.1 hypothetical protein Machinery gene
  F1537_RS06590 (F1537_06600) comA 1278782..1279579 (-) 798 WP_013526473.1 pilus assembly protein PilM Machinery gene
  F1537_RS06595 (F1537_06605) - 1279678..1282278 (+) 2601 WP_013526472.1 penicillin-binding protein 1A -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49026.34 Da        Isoelectric Point: 8.2552

>NTDB_id=385776 F1537_RS06570 WP_013526477.1 1276000..1277337(-) (comE) [Haemophilus influenzae biotype aegyptius strain HE7/F1946]
MKKYFLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVIGDTLENKISLKLDNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPVGSITFDDRSN
LLVIQDDPRSVQNIKKLISEMDKPIEQIAIEARIVTITDESLKELGIRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTATPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLAALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=385776 F1537_RS06570 WP_013526477.1 1276000..1277337(-) (comE) [Haemophilus influenzae biotype aegyptius strain HE7/F1946]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTCTAGTGTGTTTTTGTTTGCCCTTAATTGTTTTTGCTAATCCAAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCGCCTTTAGCCCAAACATTGGAACAGTTGGCTTTTCAACAAGATG
TAAATTTAGTGATTGGAGATACATTGGAAAACAAGATCTCTTTAAAATTAGACAATATTGATATGCCACGTTTGCTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGATGAGGGTATTTATTATCTGAATGGAGGGCAATCAGGCAAAGG
TCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACCACAGGAAGTGGCTCTTTACTTTCACCCGTTGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTAGTTATTCAGGATGATCCTCGTTCTGTACAAAATATCAAAAAACTGATTTCTGAAATGGATAAGCCTATTGAGCA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCATTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGTCTTGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGGCGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTCGATTTAGAATT
AAGCGCGTTAGAGCGTGAAAATAATGTGGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAAGGTACAGAAATTCCTTATGTTGTGAGTAATACTCGTAACGATACACAATCTGTGGAATTTCGCGAGGCGGTG
CTAGGTTTGGAAGTCACTCCACATATTTCCAAAGATAATAATATTTTGCTTGATTTATTAGTGAGTCAAAATTCCCCCGG
TTCTCGTGTCGCTTATGGACAAAACGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACTATTGTGCTTGGTGGCGTGTTCCACGATACGATCACTAAAAGCGAAGATAAAGTGCCATTACTTGGCGATATA
CCCGTCATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGTTAGTGATTTTCGTGACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGCGGCCTTGAAACAAAAAAGTGCGGGGAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)

Bacterial type II and III secretion system protein (Secretin)

(269-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

96.854

100

0.969
  comE Haemophilus influenzae 86-028NP

95.056

100

0.951
  comE Glaesserella parasuis strain SC1401

52.706

95.506

0.503
  pilQ Vibrio campbellii strain DS40M4

42.482

94.157

0.4
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.748

92.584

0.387
  pilQ Vibrio cholerae strain A1552

41.748

92.584

0.387

Multiple sequence alignment