Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   MGAS2221_RS07160 Genome accession   NZ_CP043530
Coordinates   1408734..1408913 (-) Length   59 a.a.
NCBI ID   WP_002988813.1    Uniprot ID   Q5YAB1
Organism   Streptococcus pyogenes strain MGAS2221     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1408734..1449350 1408734..1408913 within 0


Gene organization within MGE regions


Location: 1408734..1449350
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS2221_RS07160 (MGAS2221_1429) prx 1408734..1408913 (-) 180 WP_002988813.1 hypothetical protein Regulator
  MGAS2221_RS07165 (MGAS2221_1430) sda1 1409152..1410324 (+) 1173 WP_002988811.1 streptodornase Sda1 -
  MGAS2221_RS07170 (MGAS2221_1431) - 1410440..1411636 (-) 1197 WP_002988807.1 glucosaminidase domain-containing protein -
  MGAS2221_RS07175 (MGAS2221_1433) - 1411747..1411932 (-) 186 WP_002988802.1 holin -
  MGAS2221_RS07180 (MGAS2221_1434) - 1411929..1412228 (-) 300 WP_002988799.1 hypothetical protein -
  MGAS2221_RS07185 (MGAS2221_1435) - 1412239..1412859 (-) 621 WP_002988797.1 hypothetical protein -
  MGAS2221_RS07190 (MGAS2221_1436) - 1412862..1413023 (-) 162 WP_002988795.1 hypothetical protein -
  MGAS2221_RS07195 (MGAS2221_1437) - 1413032..1414939 (-) 1908 WP_002988792.1 gp58-like family protein -
  MGAS2221_RS07200 (MGAS2221_1438) - 1414950..1415585 (-) 636 WP_002988442.1 hypothetical protein -
  MGAS2221_RS07205 (MGAS2221_1439) - 1415585..1416640 (-) 1056 WP_002988439.1 hypothetical protein -
  MGAS2221_RS07210 (MGAS2221_1440) - 1416637..1418619 (-) 1983 WP_002988790.1 phage tail protein -
  MGAS2221_RS07215 (MGAS2221_1441) - 1418629..1419471 (-) 843 WP_002988788.1 phage tail family protein -
  MGAS2221_RS07220 (MGAS2221_1442) - 1419483..1423865 (-) 4383 WP_002988786.1 tape measure protein -
  MGAS2221_RS07225 (MGAS2221_1443) - 1423880..1424113 (-) 234 WP_002983445.1 hypothetical protein -
  MGAS2221_RS07230 (MGAS2221_1444) - 1424188..1424643 (-) 456 WP_002983443.1 tail assembly chaperone -
  MGAS2221_RS07235 (MGAS2221_1445) - 1424697..1425296 (-) 600 WP_002988784.1 phage major tail protein, TP901-1 family -
  MGAS2221_RS07240 (MGAS2221_1446) - 1425308..1425667 (-) 360 WP_002988782.1 hypothetical protein -
  MGAS2221_RS07245 (MGAS2221_1447) - 1425671..1426015 (-) 345 WP_002988781.1 HK97-gp10 family putative phage morphogenesis protein -
  MGAS2221_RS07250 (MGAS2221_1448) - 1426012..1426290 (-) 279 WP_000639437.1 hypothetical protein -
  MGAS2221_RS07255 (MGAS2221_1449) - 1426301..1426657 (-) 357 WP_002988776.1 phage head-tail connector protein -
  MGAS2221_RS07260 (MGAS2221_1450) - 1426669..1427556 (-) 888 WP_002988771.1 hypothetical protein -
  MGAS2221_RS07265 (MGAS2221_1451) - 1427569..1428138 (-) 570 WP_002988768.1 DUF4355 domain-containing protein -
  MGAS2221_RS07270 (MGAS2221_1452) - 1428294..1428560 (-) 267 WP_002988765.1 hypothetical protein -
  MGAS2221_RS07275 - 1428563..1428751 (-) 189 WP_002983423.1 hypothetical protein -
  MGAS2221_RS07280 (MGAS2221_1454) - 1428782..1430227 (-) 1446 WP_015446273.1 minor capsid protein -
  MGAS2221_RS07285 (MGAS2221_1455) - 1430187..1431719 (-) 1533 WP_002988758.1 phage portal protein -
  MGAS2221_RS07290 (MGAS2221_1456) - 1431735..1433012 (-) 1278 WP_002988754.1 PBSX family phage terminase large subunit -
  MGAS2221_RS07295 (MGAS2221_1457) - 1433002..1433454 (-) 453 WP_011106637.1 terminase small subunit -
  MGAS2221_RS07300 (MGAS2221_1458) - 1433544..1433960 (-) 417 WP_002988747.1 DUF722 domain-containing protein -
  MGAS2221_RS07305 (MGAS2221_1459) - 1433957..1434148 (-) 192 WP_002988743.1 hypothetical protein -
  MGAS2221_RS07310 (MGAS2221_1460) - 1434138..1434989 (-) 852 WP_002988740.1 site-specific DNA-methyltransferase -
  MGAS2221_RS07315 (MGAS2221_1461) - 1434998..1435264 (-) 267 WP_002988738.1 hypothetical protein -
  MGAS2221_RS07320 (MGAS2221_1462) - 1435261..1435428 (-) 168 WP_002988735.1 hypothetical protein -
  MGAS2221_RS07325 (MGAS2221_1463) - 1435429..1436751 (-) 1323 WP_002988733.1 SNF2-related protein -
  MGAS2221_RS07330 (MGAS2221_1464) - 1436748..1437023 (-) 276 WP_002988730.1 VRR-NUC domain-containing protein -
  MGAS2221_RS07335 (MGAS2221_1465) - 1437410..1439794 (-) 2385 WP_011285674.1 phage/plasmid primase, P4 family -
  MGAS2221_RS07340 (MGAS2221_1466) - 1439799..1441721 (-) 1923 WP_002988723.1 DNA polymerase -
  MGAS2221_RS07345 (MGAS2221_1467) - 1441764..1442321 (-) 558 WP_002988718.1 DUF2815 family protein -
  MGAS2221_RS07350 (MGAS2221_1468) - 1442332..1442730 (-) 399 WP_002988715.1 hypothetical protein -
  MGAS2221_RS07355 (MGAS2221_1469) - 1442734..1443888 (-) 1155 WP_002988711.1 DUF2800 domain-containing protein -
  MGAS2221_RS07360 (MGAS2221_1470) - 1443888..1444187 (-) 300 WP_002988708.1 hypothetical protein -
  MGAS2221_RS07365 (MGAS2221_1471) - 1444275..1444478 (-) 204 WP_002988705.1 hypothetical protein -
  MGAS2221_RS07370 (MGAS2221_1473) - 1444624..1445010 (-) 387 WP_002988700.1 hypothetical protein -
  MGAS2221_RS07375 (MGAS2221_1474) - 1445007..1445210 (-) 204 WP_002988697.1 hypothetical protein -
  MGAS2221_RS07380 (MGAS2221_1475) - 1445203..1445373 (-) 171 WP_002988693.1 hypothetical protein -
  MGAS2221_RS07385 (MGAS2221_1476) - 1445370..1445645 (-) 276 WP_002988687.1 hypothetical protein -
  MGAS2221_RS07390 (MGAS2221_1477) - 1445707..1445922 (-) 216 WP_002988684.1 hypothetical protein -
  MGAS2221_RS07395 (MGAS2221_1478) - 1445970..1446383 (+) 414 WP_002988681.1 hypothetical protein -
  MGAS2221_RS07400 (MGAS2221_1479) - 1446364..1446519 (-) 156 WP_002988678.1 hypothetical protein -
  MGAS2221_RS07405 (MGAS2221_1480) - 1446845..1447195 (+) 351 WP_002988676.1 helix-turn-helix transcriptional regulator -
  MGAS2221_RS07410 (MGAS2221_1481) - 1447209..1447592 (+) 384 WP_002988673.1 ImmA/IrrE family metallo-endopeptidase -
  MGAS2221_RS07415 (MGAS2221_1482) - 1447603..1448154 (+) 552 WP_002988670.1 hypothetical protein -
  MGAS2221_RS07420 (MGAS2221_1483) - 1448271..1449350 (+) 1080 WP_002988667.1 tyrosine-type recombinase/integrase -

Sequence

Protein


Download         Length: 59 a.a.        Molecular weight: 6798.70 Da        Isoelectric Point: 4.2542

>NTDB_id=384854 MGAS2221_RS07160 WP_002988813.1 1408734..1408913(-) (prx) [Streptococcus pyogenes strain MGAS2221]
MLTYDEFKQAIDHGYITGDTVAIVRKNGQIFDYVLPHEKVKNGEVVTDEKVEEVLMELE

Nucleotide


Download         Length: 180 bp        

>NTDB_id=384854 MGAS2221_RS07160 WP_002988813.1 1408734..1408913(-) (prx) [Streptococcus pyogenes strain MGAS2221]
ATGCTAACATACGACGAATTTAAGCAAGCAATCGACCATGGGTATATCACAGGAGACACAGTAGCGATTGTGCGCAAAAA
CGGACAGATCTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACAGATGAAAAAGTGGAAGAAG
TGTTGATGGAATTGGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5YAB1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

91.379

98.305

0.898
  prx Streptococcus pyogenes MGAS315

87.931

98.305

0.864
  prx Streptococcus pyogenes MGAS315

84.746

100

0.847
  prx Streptococcus pyogenes MGAS315

74.576

100

0.746
  prx Streptococcus pyogenes MGAS315

86.047

72.881

0.627
  prx Streptococcus pyogenes MGAS315

90.244

69.492

0.627
  prx Streptococcus pyogenes MGAS315

80.952

71.186

0.576

Multiple sequence alignment