Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   HA248_RS10390 Genome accession   NZ_CP050175
Coordinates   1980846..1981286 (-) Length   146 a.a.
NCBI ID   WP_001206584.1    Uniprot ID   A0A0H2ZQ34
Organism   Streptococcus pneumoniae strain PZ900701590     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1975846..1986286
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HA248_RS10360 (HA248_10335) - 1976156..1977031 (+) 876 WP_000669493.1 substrate-binding domain-containing protein -
  HA248_RS10365 (HA248_10340) pstC 1977149..1978012 (+) 864 WP_000595180.1 phosphate ABC transporter permease subunit PstC -
  HA248_RS10370 (HA248_10345) pstA 1978005..1978820 (+) 816 WP_000049768.1 phosphate ABC transporter permease PstA -
  HA248_RS10375 (HA248_10350) pstB 1978822..1979574 (+) 753 WP_000536449.1 phosphate ABC transporter ATP-binding protein PstB -
  HA248_RS10380 (HA248_10355) phoU 1979589..1980239 (+) 651 WP_001245781.1 phosphate signaling complex protein PhoU -
  HA248_RS10385 (HA248_10360) - 1980301..1980723 (+) 423 Protein_2000 transposase -
  HA248_RS10390 (HA248_10365) comR 1980846..1981286 (-) 441 WP_001206584.1 helix-turn-helix transcriptional regulator Regulator
  HA248_RS10395 (HA248_10370) - 1981498..1982514 (+) 1017 WP_000415108.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  HA248_RS10400 (HA248_10375) galU 1982536..1983435 (+) 900 WP_000202229.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
  HA248_RS10405 (HA248_10380) - 1983502..1984179 (-) 678 WP_000658498.1 rhomboid family intramembrane serine protease -
  HA248_RS10410 (HA248_10385) - 1984163..1984702 (-) 540 WP_000834308.1 5-formyltetrahydrofolate cyclo-ligase -
  HA248_RS10415 (HA248_10390) - 1984714..1985844 (-) 1131 WP_000885102.1 N-acetyldiaminopimelate deacetylase -

Sequence

Protein


Download         Length: 146 a.a.        Molecular weight: 17716.41 Da        Isoelectric Point: 4.8659

>NTDB_id=377569 HA248_RS10390 WP_001206584.1 1980846..1981286(-) (comR) [Streptococcus pneumoniae strain PZ900701590]
MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRPTLTKLKYIAERLEVEDYKLMPSYIELDKEYLELKYF
LMRTPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFIIPNYSYLALANYTVQKLPEKLVEILSFW

Nucleotide


Download         Length: 441 bp        

>NTDB_id=377569 HA248_RS10390 WP_001206584.1 1980846..1981286(-) (comR) [Streptococcus pneumoniae strain PZ900701590]
TTGCGAGAGTTTGGCGAAAAAATTAAAAGATTACGTTTGGCTAAAAAAATCAGTCGTTCAGAATTTTGTGGTGATGAGTC
TGAATTAAGTATCCGTCAATTAATTAGAATTGAAAATGGAGAATCCAGACCAACACTAACAAAGTTAAAATATATTGCTG
AACGTTTGGAGGTTGAAGATTACAAGTTGATGCCAAGTTATATAGAGTTGGATAAGGAATACCTAGAATTGAAGTATTTC
TTGATGAGGACTCCTACATACGAAGATGAAACTATCGCCCAAAAGAAAGAGAGTGTTTTTGATAAGATTTTTGAAGAGTA
TTATGATAGGCTACCTGAGGAAGAAAGATTTATCATCCCAAATTATTCATATCTAGCACTAGCGAACTACACAGTTCAAA
AATTACCAGAAAAGCTAGTTGAAATACTGTCCTTCTGGTGA

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(72-119)

Helix-turn-helix (HTH_3)

(8-59)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2ZQ34

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

55

82.192

0.452
  comR Streptococcus pyogenes MGAS315

53.333

82.192

0.438
  comR Streptococcus mutans UA159

52.5

82.192

0.432
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

53.636

75.342

0.404
  comR Streptococcus suis P1/7

47.458

80.822

0.384
  comR Streptococcus suis 05ZYH33

47.458

80.822

0.384
  comR Streptococcus suis D9

46.61

80.822

0.377
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

47.368

78.082

0.37