Detailed information NTG0037607

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: HMPREF0837_RS06110
• Genome accession: NC_014251
• Coordinates: 1171482..1172186 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae TCH8431/19A
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1166482..1177186

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS06090 (HMPREF0837_11269)	coaC	1166771..1167322 (-)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-
HMPREF0837_RS06095 (HMPREF0837_11270)	coaB	1167334..1168023 (-)	690	WP_000699489.1	phosphopantothenate--cysteine ligase	-
HMPREF0837_RS06100 (HMPREF0837_11271)	-	1168253..1169923 (+)	1671	WP_000845287.1	formate--tetrahydrofolate ligase	-
HMPREF0837_RS06105 (HMPREF0837_11274)	mutY	1170252..1171427 (+)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
HMPREF0837_RS06110 (HMPREF0837_11275)	micA	1171482..1172186 (+)	705	WP_000722076.1	response regulator YycF	Regulator
HMPREF0837_RS06115 (HMPREF0837_11276)	micB	1172179..1173528 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HMPREF0837_RS06120 (HMPREF0837_11277)	vicX	1173530..1174339 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
HMPREF0837_RS06125 (HMPREF0837_11278)	relB	1174430..1174672 (+)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
HMPREF0837_RS06130 (HMPREF0837_11279)	-	1174674..1174928 (+)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HMPREF0837_RS06135 (HMPREF0837_11280)	-	1174975..1175748 (+)	774	WP_000731129.1	potassium channel family protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=37607 HMPREF0837_RS06110 WP_000722076.1 1171482..1172186(+) (micA) [Streptococcus pneumoniae TCH8431/19A]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=37607 HMPREF0837_RS06110 WP_000722076.1 1171482..1172186(+) (micA) [Streptococcus pneumoniae TCH8431/19A]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38