Detailed information NTG0037608

Bioinformatically predicted

Overview

• Name: micB
• Type: Regulator
• Locus tag: HMPREF0837_RS06115
• Genome accession: NC_014251
• Coordinates: 1172179..1173528 (+)
• Length: 449 a.a.
• NCBI ID: WP_000886210.1
• Uniprot ID: A0A064BZM9
• Organism: Streptococcus pneumoniae TCH8431/19A
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1167179..1178528

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS06095 (HMPREF0837_11270)	coaB	1167334..1168023 (-)	690	WP_000699489.1	phosphopantothenate--cysteine ligase	-
HMPREF0837_RS06100 (HMPREF0837_11271)	-	1168253..1169923 (+)	1671	WP_000845287.1	formate--tetrahydrofolate ligase	-
HMPREF0837_RS06105 (HMPREF0837_11274)	mutY	1170252..1171427 (+)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
HMPREF0837_RS06110 (HMPREF0837_11275)	micA	1171482..1172186 (+)	705	WP_000722076.1	response regulator YycF	Regulator
HMPREF0837_RS06115 (HMPREF0837_11276)	micB	1172179..1173528 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HMPREF0837_RS06120 (HMPREF0837_11277)	vicX	1173530..1174339 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
HMPREF0837_RS06125 (HMPREF0837_11278)	relB	1174430..1174672 (+)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
HMPREF0837_RS06130 (HMPREF0837_11279)	-	1174674..1174928 (+)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HMPREF0837_RS06135 (HMPREF0837_11280)	-	1174975..1175748 (+)	774	WP_000731129.1	potassium channel family protein	-
HMPREF0837_RS06140 (HMPREF0837_11281)	-	1176064..1177410 (-)	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51712.42 Da
• Isoelectric Point: 4.9706

>NTDB_id=37608 HMPREF0837_RS06115 WP_000886210.1 1172179..1173528(+) (micB) [Streptococcus pneumoniae TCH8431/19A]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide

• Length: 1350 bp

>NTDB_id=37608 HMPREF0837_RS06115 WP_000886210.1 1172179..1173528(+) (micB) [Streptococcus pneumoniae TCH8431/19A]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

• PAS fold (PAS) (98-198)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (324-434)

3D structure

• AlphaFold DB: A0A064BZM9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micB	Streptococcus pneumoniae Cp1015	99.777	100	0.998
vicK	Streptococcus mutans UA159	69.9	89.532	0.626