Detailed information NTG0374427

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: G8B43_RS08130
• Genome accession: NZ_CP049689
• Coordinates: 1587805..1588395 (-)
• Length: 196 a.a.
• NCBI ID: WP_002985850.1
• Uniprot ID: A0A9X9QW05
• Organism: Streptococcus pyogenes strain ABC221
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1582805..1593395

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B43_RS08095 (G8B43_08155)	-	1582986..1583378 (-)	393	WP_002985833.1	DUF5684 domain-containing protein	-
G8B43_RS08100 (G8B43_08160)	rsmI	1583405..1584268 (-)	864	WP_002990904.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
G8B43_RS08105 (G8B43_08165)	yabA	1584273..1584596 (-)	324	WP_002985838.1	DNA replication initiation control protein YabA	-
G8B43_RS08110	-	1585000..1585239 (-)	240	WP_021299187.1	PSP1 C-terminal domain-containing protein	-
G8B43_RS08115 (G8B43_08175)	-	1585258..1586133 (-)	876	WP_011528291.1	DNA polymerase III subunit delta'	-
G8B43_RS08120 (G8B43_08180)	tmk	1586151..1586786 (-)	636	WP_021299190.1	dTMP kinase	-
G8B43_RS08125 (G8B43_08185)	-	1587017..1587310 (-)	294	WP_002990928.1	YlbG family protein	-
G8B43_RS08130 (G8B43_08190)	clpP	1587805..1588395 (-)	591	WP_002985850.1	ATP-dependent Clp protease proteolytic subunit	Regulator
G8B43_RS08135 (G8B43_08195)	upp	1588619..1589248 (-)	630	WP_002985854.1	uracil phosphoribosyltransferase	-
G8B43_RS08140 (G8B43_08200)	-	1589416..1591050 (-)	1635	WP_011528289.1	polysaccharide biosynthesis protein	-
G8B43_RS08145 (G8B43_08205)	-	1591138..1592583 (+)	1446	WP_021299191.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21648.88 Da
• Isoelectric Point: 5.2834

>NTDB_id=374427 G8B43_RS08130 WP_002985850.1 1587805..1588395(-) (clpP) [Streptococcus pyogenes strain ABC221]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=374427 G8B43_RS08130 WP_002985850.1 1587805..1588395(-) (clpP) [Streptococcus pyogenes strain ABC221]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A9X9QW05

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pyogenes MGAS315	100	100	1
clpP	Streptococcus pyogenes JRS4	100	100	1
clpP	Streptococcus mutans UA159	90.816	100	0.908
clpP	Streptococcus pneumoniae Rx1	90.769	99.49	0.903
clpP	Streptococcus pneumoniae D39	90.769	99.49	0.903
clpP	Streptococcus pneumoniae R6	90.769	99.49	0.903
clpP	Streptococcus pneumoniae TIGR4	90.769	99.49	0.903
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	86.224	100	0.862
clpP	Lactococcus lactis subsp. cremoris KW2	85.714	100	0.857
clpP	Bacillus subtilis subsp. subtilis str. 168	57.143	100	0.571
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.995	98.469	0.561