Detailed information NTG0367360

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FHI56_RS08030
• Genome accession: NZ_CP040804
• Coordinates: 1399772..1400446 (-)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain LAB813
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1394772..1405446

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FHI56_RS08005 (FHI56_08005)	-	1395086..1396363 (-)	1278	WP_118058063.1	pyrimidine-nucleoside phosphorylase	-
FHI56_RS08010 (FHI56_08010)	-	1396360..1396950 (-)	591	WP_004182394.1	class I SAM-dependent methyltransferase	-
FHI56_RS08015 (FHI56_08015)	coaA	1397063..1397983 (+)	921	WP_004182393.1	type I pantothenate kinase	-
FHI56_RS08020 (FHI56_08020)	rpsT	1398053..1398289 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
FHI56_RS08025 (FHI56_08025)	ciaH	1398367..1399782 (-)	1416	WP_045772383.1	cell wall metabolism sensor histidine kinase WalK	Regulator
FHI56_RS08030 (FHI56_08030)	ciaR	1399772..1400446 (-)	675	WP_002891134.1	response regulator transcription factor	Regulator
FHI56_RS08035 (FHI56_08035)	-	1400645..1402315 (-)	1671	WP_149561360.1	formate--tetrahydrofolate ligase	-
FHI56_RS08040 (FHI56_08040)	-	1402521..1403204 (+)	684	WP_004182113.1	phosphopantothenate--cysteine ligase	-
FHI56_RS08045 (FHI56_08045)	coaC	1403197..1403742 (+)	546	WP_004182014.1	phosphopantothenoylcysteine decarboxylase	-
FHI56_RS08050 (FHI56_08050)	-	1403771..1404343 (+)	573	WP_004182105.1	ECF transporter S component	-
FHI56_RS08055 (FHI56_08055)	-	1404410..1404970 (+)	561	WP_004182060.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=367360 FHI56_RS08030 WP_002891134.1 1399772..1400446(-) (ciaR) [Streptococcus salivarius strain LAB813]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=367360 FHI56_RS08030 WP_002891134.1 1399772..1400446(-) (ciaR) [Streptococcus salivarius strain LAB813]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362