Detailed information NTG0367215

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: FDP16_RS03970
• Genome accession: NZ_CP040798
• Coordinates: 766646..767347 (+)
• Length: 233 a.a.
• NCBI ID: WP_176798655.1
• Uniprot ID: A0A7H8UZI4
• Organism: Streptococcus sanguinis strain CGMH058
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 761646..772347

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FDP16_RS12065 (FDP16_04085)	-	761807..762167 (-)	361	Protein_752	MerR family transcriptional regulator	-
FDP16_RS03940 (FDP16_04090)	-	762244..762621 (+)	378	WP_176798651.1	carboxymuconolactone decarboxylase family protein	-
FDP16_RS03945 (FDP16_04095)	-	762847..763245 (-)	399	WP_176798652.1	hypothetical protein	-
FDP16_RS03950 (FDP16_04100)	-	763355..764014 (-)	660	WP_002912899.1	amino acid ABC transporter permease	-
FDP16_RS03955 (FDP16_04105)	-	764025..764705 (-)	681	WP_009659278.1	amino acid ABC transporter permease	-
FDP16_RS03960 (FDP16_04110)	-	764718..765530 (-)	813	WP_176798653.1	transporter substrate-binding domain-containing protein	-
FDP16_RS03965 (FDP16_04115)	-	765545..766306 (-)	762	WP_176798654.1	amino acid ABC transporter ATP-binding protein	-
FDP16_RS03970 (FDP16_04120)	micA	766646..767347 (+)	702	WP_176798655.1	response regulator YycF	Regulator
FDP16_RS03975 (FDP16_04125)	micB	767340..768689 (+)	1350	WP_125331413.1	cell wall metabolism sensor histidine kinase VicK	Regulator
FDP16_RS03980 (FDP16_04130)	vicX	768699..769499 (+)	801	WP_176798656.1	MBL fold metallo-hydrolase	Regulator
FDP16_RS03985 (FDP16_04135)	-	769591..769950 (+)	360	WP_176798657.1	YbaN family protein	-
FDP16_RS03990 (FDP16_04140)	rnc	770072..770770 (+)	699	WP_002903151.1	ribonuclease III	-

Sequence

Protein

• Length: 233 a.a.
• Molecular weight: 26791.74 Da
• Isoelectric Point: 4.7458

>NTDB_id=367215 FDP16_RS03970 WP_176798655.1 766646..767347(+) (micA) [Streptococcus sanguinis strain CGMH058]
MKKILVVDDEKPISDIIKFNMVKEGYEVLTAFDGKEALEMFEVEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 702 bp

>NTDB_id=367215 FDP16_RS03970 WP_176798655.1 766646..767347(+) (micA) [Streptococcus sanguinis strain CGMH058]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGTCAAAGAAGGCTATGA
GGTTTTGACTGCTTTTGATGGTAAGGAAGCCTTGGAAATGTTTGAGGTAGAACAGCCAGATATCTTGATTCTGGACTTGA
TGCTGCCAGAAGTGGATGGACTGGAAGTTGCTCGGACTATTCGCAAGACCAGCAATGTTCCGATTATTGTATTATCTGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGCCTTGAAATCGGTGCAGATGACTATGTGACTAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTCAAGGCACTTCTTCGTCGGGCAGACCTTGTTGTGGAAAACCAAGTAGAAGAAAGTGGTCCGAACG
AGTTGACCATTGGGGAACTGCAGATTTTGCCAGATGCTTTTGTTGCTAAGAAGCATGGTAAGGAGCTGGAGCTGACCCAC
CGTGAGTTTGAGTTGCTTCACCATTTGGCGACACATATCGGTCAGGTGATGACACGTGAGCACTTGCTGGAAACAGTATG
GGGCTATGACTATTTTGGTGATGTCCGTACAGTGGATGTGACTATCCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGGCCTGAGTATATCTTGACTCGCCGCGGAGTTGGGTACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-228)

3D structure

• AlphaFold DB: A0A7H8UZI4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	82.403	100	0.824
vicR	Streptococcus mutans UA159	80	100	0.807
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.231	98.283	0.425
covR	Streptococcus salivarius strain HSISS4	42.174	98.712	0.416
scnR	Streptococcus mutans UA159	36.957	98.712	0.365