Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   FDP16_RS03245 Genome accession   NZ_CP040798
Coordinates   637646..638263 (+) Length   205 a.a.
NCBI ID   WP_256254472.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain CGMH058     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 619121..650273 637646..638263 within 0


Gene organization within MGE regions


Location: 619121..650273
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FDP16_RS03130 (FDP16_03240) - 619121..620056 (+) 936 WP_176798538.1 manganese-dependent inorganic pyrophosphatase -
  FDP16_RS03135 (FDP16_03245) - 620149..620661 (+) 513 WP_176798539.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
  FDP16_RS03140 (FDP16_03250) - 620654..620812 (+) 159 Protein_586 DUF1803 domain-containing protein -
  FDP16_RS03145 (FDP16_03255) - 620967..621290 (+) 324 WP_176798540.1 DUF2568 domain-containing protein -
  FDP16_RS03150 (FDP16_03260) - 621335..621988 (+) 654 WP_176798541.1 DUF1803 domain-containing protein -
  FDP16_RS03155 (FDP16_03265) - 622090..622284 (+) 195 WP_176798542.1 CsbD family protein -
  FDP16_RS03160 (FDP16_03270) - 622522..623277 (+) 756 WP_218134319.1 CPBP family intramembrane glutamic endopeptidase -
  FDP16_RS03165 (FDP16_03275) - 623457..624902 (-) 1446 WP_176798544.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase -
  FDP16_RS03170 (FDP16_03280) - 624989..626617 (+) 1629 WP_176798545.1 polysaccharide biosynthesis protein -
  FDP16_RS03175 (FDP16_03285) - 627031..627447 (-) 417 WP_176798546.1 DUF1492 domain-containing protein -
  FDP16_RS03180 (FDP16_03290) - 627561..627782 (+) 222 WP_176798547.1 hypothetical protein -
  FDP16_RS11760 (FDP16_03295) - 627889..628395 (-) 507 WP_256254471.1 hypothetical protein -
  FDP16_RS03185 (FDP16_03300) - 628492..629019 (-) 528 WP_176798548.1 hypothetical protein -
  FDP16_RS03190 (FDP16_03305) - 629042..629764 (-) 723 WP_176798549.1 ATP-binding protein -
  FDP16_RS03195 (FDP16_03310) - 629775..630626 (-) 852 WP_176798550.1 DnaD domain protein -
  FDP16_RS03200 (FDP16_03315) - 630619..630894 (-) 276 WP_176798551.1 MerR family transcriptional regulator -
  FDP16_RS03205 (FDP16_03320) - 630902..631240 (-) 339 WP_176798552.1 hypothetical protein -
  FDP16_RS11765 - 631264..631398 (-) 135 WP_256254400.1 hypothetical protein -
  FDP16_RS03210 (FDP16_03325) - 631853..632089 (-) 237 WP_176798553.1 hypothetical protein -
  FDP16_RS03215 (FDP16_03330) - 632104..632289 (-) 186 WP_176798554.1 hypothetical protein -
  FDP16_RS03220 (FDP16_03335) - 632444..632944 (+) 501 WP_176798555.1 helix-turn-helix transcriptional regulator -
  FDP16_RS03225 (FDP16_03340) - 633034..634290 (+) 1257 WP_176798556.1 site-specific integrase -
  FDP16_RS03230 (FDP16_03345) - 634448..635605 (+) 1158 WP_176798557.1 cystathionine gamma-synthase -
  FDP16_RS03235 (FDP16_03350) - 635607..636773 (+) 1167 WP_176798558.1 MalY/PatB family protein -
  FDP16_RS03240 (FDP16_03360) upp 636936..637565 (+) 630 WP_002903228.1 uracil phosphoribosyltransferase -
  FDP16_RS03245 (FDP16_03365) clpP 637646..638263 (+) 618 WP_256254472.1 ATP-dependent Clp protease proteolytic subunit Regulator
  FDP16_RS03250 (FDP16_03370) - 638416..638685 (+) 270 WP_176798560.1 YlbG family protein -
  FDP16_RS03255 (FDP16_03375) - 638774..639934 (+) 1161 WP_176798561.1 ABC transporter substrate-binding protein -
  FDP16_RS03260 (FDP16_03380) - 640184..641053 (+) 870 WP_176798562.1 branched-chain amino acid ABC transporter permease -
  FDP16_RS03265 (FDP16_03385) - 641057..642010 (+) 954 WP_125331161.1 branched-chain amino acid ABC transporter permease -
  FDP16_RS03270 (FDP16_03390) - 642010..642774 (+) 765 WP_176798563.1 ABC transporter ATP-binding protein -
  FDP16_RS03275 (FDP16_03395) - 642774..643484 (+) 711 WP_002894681.1 ABC transporter ATP-binding protein -
  FDP16_RS03280 (FDP16_03400) - 644294..644950 (+) 657 WP_176798564.1 CBS domain-containing protein -
  FDP16_RS03285 (FDP16_03405) - 644986..645873 (-) 888 WP_176798565.1 YitT family protein -
  FDP16_RS03290 (FDP16_03415) tmk 646187..646825 (+) 639 WP_176798566.1 dTMP kinase -
  FDP16_RS03295 (FDP16_03420) - 646822..647712 (+) 891 WP_176798567.1 DNA polymerase III subunit delta' -
  FDP16_RS03300 (FDP16_03425) yabA 647737..648054 (+) 318 WP_002894690.1 DNA replication initiation control protein YabA -
  FDP16_RS03305 (FDP16_03430) rsmI 648057..648923 (+) 867 WP_176798568.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
  FDP16_RS03310 (FDP16_03435) serC 649182..650273 (+) 1092 WP_176798569.1 3-phosphoserine/phosphohydroxythreonine transaminase -

Sequence

Protein


Download         Length: 205 a.a.        Molecular weight: 22712.94 Da        Isoelectric Point: 4.7792

>NTDB_id=367213 FDP16_RS03245 WP_256254472.1 637646..638263(+) (clpP) [Streptococcus sanguinis strain CGMH058]
MLKREREKTMIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSA
GLAIVDTMNFIKSDVQTIVMGVAASMGTVIASSGAKGKRFMLPNAEYLIHQPMGGAGSGTQQTDMAIVAEHLLRTRNTLE
KILAENSGKSVEQIHKDAERDYWMSAQETLEYGFIDEIMENSNLS

Nucleotide


Download         Length: 618 bp        

>NTDB_id=367213 FDP16_RS03245 WP_256254472.1 637646..638263(+) (clpP) [Streptococcus sanguinis strain CGMH058]
ATTTTAAAAAGAGAAAGAGAGAAAACTATGATTCCTGTAGTTATTGAACAAACCAGCCGAGGGGAGCGCTCCTATGACAT
TTATTCTCGGCTATTAAAAGATCGGATTATCATGCTGACTGGTCCAGTAGAGGATAATATGGCTAATTCAATCATTGCCC
AGCTCCTTTTCTTGGATGCACAGGACAATACTAAAGATATTTATCTCTATGTAAATACGCCGGGTGGTTCTGTTTCAGCA
GGTCTGGCTATTGTGGACACTATGAACTTCATCAAGTCTGATGTTCAGACCATTGTTATGGGTGTAGCTGCCAGCATGGG
AACGGTCATTGCTTCCAGTGGTGCCAAAGGCAAACGCTTCATGCTTCCAAATGCAGAATATCTGATTCACCAGCCGATGG
GCGGAGCTGGAAGCGGCACTCAGCAAACGGATATGGCAATTGTAGCTGAGCACTTGCTTAGAACTCGGAATACCTTGGAA
AAAATCTTGGCAGAAAACTCTGGTAAGTCTGTTGAGCAAATCCACAAGGATGCAGAGCGTGATTACTGGATGAGTGCTCA
AGAAACTTTGGAATACGGCTTTATTGACGAAATCATGGAAAATAGCAATTTAAGCTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(20-201)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae R6

90.306

95.61

0.863
  clpP Streptococcus pneumoniae Rx1

90.306

95.61

0.863
  clpP Streptococcus pneumoniae D39

90.306

95.61

0.863
  clpP Streptococcus pneumoniae TIGR4

90.306

95.61

0.863
  clpP Streptococcus pyogenes JRS4

89.744

95.122

0.854
  clpP Streptococcus pyogenes MGAS315

89.744

95.122

0.854
  clpP Streptococcus mutans UA159

87.5

97.561

0.854
  clpP Streptococcus thermophilus LMG 18311

88.718

95.122

0.844
  clpP Streptococcus thermophilus LMD-9

88.718

95.122

0.844
  clpP Lactococcus lactis subsp. cremoris KW2

87.692

95.122

0.834
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

87.179

95.122

0.829
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

60.104

94.146

0.566
  clpP Bacillus subtilis subsp. subtilis str. 168

56.995

94.146

0.537

Multiple sequence alignment