Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   ES298_RS11245 Genome accession   NZ_CP038253
Coordinates   504276..504863 (-) Length   195 a.a.
NCBI ID   WP_001810228.1    Uniprot ID   A0A380LSF4
Organism   Streptococcus pneumoniae strain TVO_1901929     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 499276..509863
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ES298_RS02525 (ES298_02660) - 499740..501080 (+) 1341 WP_001017638.1 sensor histidine kinase -
  ES298_RS02530 (ES298_02665) blpC 501122..501277 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  ES298_RS02535 (ES298_02670) - 501334..502695 (-) 1362 WP_001069091.1 bacteriocin secretion accessory protein -
  ES298_RS02540 (ES298_02675) comA/nlmT 502706..504382 (-) 1677 WP_196299874.1 peptide cleavage/export ABC transporter Regulator
  ES298_RS11245 comA/nlmT 504276..504863 (-) 588 WP_001810228.1 cysteine peptidase family C39 domain-containing protein Regulator
  ES298_RS02545 (ES298_02680) blpI 505145..505342 (+) 198 WP_001093259.1 bacteriocin-like peptide BlpI -
  ES298_RS02550 (ES298_02690) blpJ 505809..506078 (+) 270 WP_001093248.1 bacteriocin-like peptide BlpJ -
  ES298_RS02555 (ES298_02695) blpU 506147..506377 (+) 231 WP_000379964.1 bacteriocin-like peptide BlpU -
  ES298_RS02560 (ES298_02700) - 506380..506499 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  ES298_RS02565 (ES298_02705) - 506796..506960 (+) 165 WP_000727118.1 hypothetical protein -
  ES298_RS02570 (ES298_02710) - 506957..507361 (+) 405 WP_000846944.1 hypothetical protein -
  ES298_RS02575 (ES298_02715) - 507559..508363 (+) 805 Protein_514 IS5 family transposase -
  ES298_RS02580 (ES298_02720) blpM 508513..508767 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  ES298_RS02585 (ES298_02725) blpN 508783..508986 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  ES298_RS02590 (ES298_02735) cipB 509230..509379 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator
  ES298_RS02595 (ES298_02740) - 509483..509602 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 195 a.a.        Molecular weight: 22369.84 Da        Isoelectric Point: 9.7306

>NTDB_id=352754 ES298_RS11245 WP_001810228.1 504276..504863(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901929]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR

Nucleotide


Download         Length: 588 bp        

>NTDB_id=352754 ES298_RS11245 WP_001810228.1 504276..504863(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901929]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTAGATGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380LSF4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

59.89

93.333

0.559
  comA Streptococcus mitis NCTC 12261

54.891

94.359

0.518
  comA Streptococcus mitis SK321

54.348

94.359

0.513
  comA Streptococcus pneumoniae TIGR4

53.804

94.359

0.508
  comA Streptococcus pneumoniae Rx1

53.804

94.359

0.508
  comA Streptococcus pneumoniae D39

53.804

94.359

0.508
  comA Streptococcus pneumoniae R6

53.804

94.359

0.508
  comA Streptococcus gordonii str. Challis substr. CH1

52.717

94.359

0.497

Multiple sequence alignment