Detailed information NTG0351092

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: GL186_RS03315
• Genome accession: NZ_CP046358
• Coordinates: 658720..659310 (+)
• Length: 196 a.a.
• NCBI ID: WP_000613477.1
• Uniprot ID: P63787
• Organism: Streptococcus pneumoniae strain 566
• Function: degradation of ComX; degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 653720..664310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL186_RS03285 (GL186_03385)	-	654106..654561 (-)	456	WP_001823744.1	8-oxo-dGTP diphosphatase	-
GL186_RS03290 (GL186_03390)	-	654581..655756 (-)	1176	WP_197097173.1	NAD(P)/FAD-dependent oxidoreductase	-
GL186_RS03295 (GL186_03395)	-	655815..656660 (-)	846	WP_000219939.1	DegV family protein	-
GL186_RS03300 (GL186_03400)	-	656785..657342 (+)	558	WP_000004139.1	TetR/AcrR family transcriptional regulator	-
GL186_RS03305 (GL186_03405)	-	657361..657828 (+)	468	WP_000136976.1	deoxycytidylate deaminase	-
GL186_RS03310 (GL186_03410)	upp	657917..658546 (+)	630	WP_001812010.1	uracil phosphoribosyltransferase	-
GL186_RS03315 (GL186_03415)	clpP	658720..659310 (+)	591	WP_000613477.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
GL186_RS03320 (GL186_03420)	-	659389..659637 (+)	249	WP_000462126.1	YlbG family protein	-
GL186_RS03325 (GL186_03425)	-	659738..660898 (+)	1161	WP_000726146.1	ABC transporter substrate-binding protein	-
GL186_RS03330 (GL186_03430)	-	661166..662035 (+)	870	WP_000941421.1	branched-chain amino acid ABC transporter permease	-
GL186_RS03335 (GL186_03435)	-	662039..662995 (+)	957	WP_000662292.1	branched-chain amino acid ABC transporter permease	-
GL186_RS03340 (GL186_03440)	-	662995..663759 (+)	765	WP_001186003.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21358.36 Da
• Isoelectric Point: 4.4910

>NTDB_id=351092 GL186_RS03315 WP_000613477.1 658720..659310(+) (clpP) [Streptococcus pneumoniae strain 566]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide

• Length: 591 bp

>NTDB_id=351092 GL186_RS03315 WP_000613477.1 658720..659310(+) (clpP) [Streptococcus pneumoniae strain 566]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: P63787

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pneumoniae Rx1	100	100	1
clpP	Streptococcus pneumoniae D39	100	100	1
clpP	Streptococcus pneumoniae R6	100	100	1
clpP	Streptococcus pneumoniae TIGR4	100	100	1
clpP	Streptococcus thermophilus LMG 18311	92.821	99.49	0.923
clpP	Streptococcus thermophilus LMD-9	92.821	99.49	0.923
clpP	Streptococcus pyogenes JRS4	90.769	99.49	0.903
clpP	Streptococcus pyogenes MGAS315	90.769	99.49	0.903
clpP	Streptococcus mutans UA159	85.714	100	0.857
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	85.128	99.49	0.847
clpP	Lactococcus lactis subsp. cremoris KW2	84.615	99.49	0.842
clpP	Bacillus subtilis subsp. subtilis str. 168	58.854	97.959	0.577
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.031	98.469	0.571