Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ETT69_RS05350 Genome accession   NZ_CP035430
Coordinates   1018756..1019430 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm55     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1013756..1024430
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT69_RS05325 (ETT69_05315) - 1014203..1014592 (-) 390 WP_011285547.1 cytidine deaminase -
  ETT69_RS05330 (ETT69_05320) - 1015245..1015838 (-) 594 WP_010922352.1 class I SAM-dependent methyltransferase -
  ETT69_RS05335 (ETT69_05325) coaA 1016106..1017026 (+) 921 WP_023610818.1 type I pantothenate kinase -
  ETT69_RS05340 (ETT69_05330) rpsT 1017080..1017328 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  ETT69_RS05345 (ETT69_05335) ciaH 1017453..1018763 (-) 1311 WP_011054528.1 cell wall metabolism sensor histidine kinase WalK Regulator
  ETT69_RS05350 (ETT69_05340) ciaR 1018756..1019430 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  ETT69_RS05355 (ETT69_05345) - 1019777..1022314 (-) 2538 WP_136019391.1 M1 family metallopeptidase -
  ETT69_RS05365 (ETT69_05355) phoU 1022519..1023172 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  ETT69_RS05370 (ETT69_05360) pstB 1023240..1023998 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=341173 ETT69_RS05350 WP_002984519.1 1018756..1019430(-) (ciaR) [Streptococcus pyogenes strain emm55]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=341173 ETT69_RS05350 WP_002984519.1 1018756..1019430(-) (ciaR) [Streptococcus pyogenes strain emm55]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGAGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACCAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment