Detailed information
Bioinformatically predicted
Overview
| Name | prx | Type | Regulator |
| Locus tag | ETT70_RS05275 | Genome accession | NZ_CP035429 |
| Coordinates | 1006447..1006590 (-) | Length | 47 a.a. |
| NCBI ID | WP_136113944.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain emmNA | ||
| Function | Inhibit ComR activation (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 998818..1047388 | 1006447..1006590 | within | 0 |
Gene organization within MGE regions
Location: 998818..1047388
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT70_RS05240 (ETT70_05230) | pfkA | 998818..999831 (-) | 1014 | WP_002984444.1 | 6-phosphofructokinase | - |
| ETT70_RS05245 (ETT70_05235) | - | 999911..1003021 (-) | 3111 | WP_136275856.1 | DNA polymerase III subunit alpha | - |
| ETT70_RS05250 (ETT70_05240) | - | 1003206..1003577 (+) | 372 | WP_002989617.1 | GntR family transcriptional regulator | - |
| ETT70_RS05255 (ETT70_05245) | - | 1003577..1004275 (+) | 699 | WP_002984437.1 | ABC transporter ATP-binding protein | - |
| ETT70_RS05260 (ETT70_05250) | - | 1004285..1005070 (+) | 786 | WP_002984433.1 | hypothetical protein | - |
| ETT70_RS05265 (ETT70_05255) | - | 1005197..1005811 (-) | 615 | WP_002989607.1 | TVP38/TMEM64 family protein | - |
| ETT70_RS05275 (ETT70_05265) | prx | 1006447..1006590 (-) | 144 | WP_136113944.1 | Paratox | Regulator |
| ETT70_RS05280 (ETT70_05270) | - | 1007286..1008494 (-) | 1209 | WP_136275997.1 | glucosaminidase domain-containing protein | - |
| ETT70_RS05285 (ETT70_05275) | - | 1008605..1008790 (-) | 186 | WP_011054731.1 | holin | - |
| ETT70_RS05290 (ETT70_05280) | - | 1008787..1009083 (-) | 297 | WP_023078532.1 | hypothetical protein | - |
| ETT70_RS05295 (ETT70_05285) | - | 1009094..1009705 (-) | 612 | WP_136275996.1 | DUF1366 domain-containing protein | - |
| ETT70_RS05300 (ETT70_05290) | - | 1009708..1010139 (-) | 432 | WP_063632964.1 | DUF1617 family protein | - |
| ETT70_RS05305 (ETT70_05295) | - | 1010151..1012037 (-) | 1887 | WP_136059201.1 | gp58-like family protein | - |
| ETT70_RS05310 (ETT70_05300) | - | 1012047..1013048 (-) | 1002 | WP_136275995.1 | hyaluronoglucosaminidase | - |
| ETT70_RS05315 (ETT70_05305) | - | 1013045..1015153 (-) | 2109 | WP_136275994.1 | phage tail spike protein | - |
| ETT70_RS05320 (ETT70_05310) | - | 1015150..1015920 (-) | 771 | WP_136040103.1 | distal tail protein Dit | - |
| ETT70_RS05325 (ETT70_05315) | - | 1015920..1018667 (-) | 2748 | WP_136133681.1 | phage tail tape measure protein | - |
| ETT70_RS05330 (ETT70_05320) | - | 1018668..1018985 (-) | 318 | WP_136059197.1 | hypothetical protein | - |
| ETT70_RS05335 (ETT70_05325) | - | 1019006..1019374 (-) | 369 | WP_136059196.1 | tail assembly chaperone | - |
| ETT70_RS05340 (ETT70_05330) | - | 1019423..1019953 (-) | 531 | WP_136059195.1 | phage major tail protein, TP901-1 family | - |
| ETT70_RS05345 (ETT70_05335) | - | 1019954..1020340 (-) | 387 | WP_136059194.1 | DUF3168 domain-containing protein | - |
| ETT70_RS05350 (ETT70_05340) | - | 1020337..1020693 (-) | 357 | WP_115225223.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| ETT70_RS05355 (ETT70_05345) | - | 1020693..1020989 (-) | 297 | WP_002992595.1 | hypothetical protein | - |
| ETT70_RS05360 (ETT70_05350) | - | 1020986..1021339 (-) | 354 | WP_002992594.1 | phage head-tail connector protein | - |
| ETT70_RS05365 (ETT70_05355) | - | 1021349..1021618 (-) | 270 | WP_136106670.1 | HeH/LEM domain-containing protein | - |
| ETT70_RS05370 (ETT70_05360) | - | 1021630..1022679 (-) | 1050 | WP_136040111.1 | major capsid protein | - |
| ETT70_RS05375 (ETT70_05365) | - | 1022682..1023062 (-) | 381 | WP_002990036.1 | structural protein | - |
| ETT70_RS05380 (ETT70_05370) | - | 1023072..1023605 (-) | 534 | WP_136106671.1 | DUF4355 domain-containing protein | - |
| ETT70_RS09230 | - | 1023712..1023882 (-) | 171 | WP_168625199.1 | hypothetical protein | - |
| ETT70_RS05385 (ETT70_05375) | - | 1023873..1024148 (-) | 276 | WP_136095084.1 | hypothetical protein | - |
| ETT70_RS05390 (ETT70_05380) | - | 1024164..1025078 (-) | 915 | WP_136059192.1 | minor capsid protein | - |
| ETT70_RS05395 (ETT70_05385) | - | 1025059..1026549 (-) | 1491 | WP_136059191.1 | phage portal protein | - |
| ETT70_RS05400 (ETT70_05390) | - | 1026561..1027805 (-) | 1245 | WP_023611361.1 | PBSX family phage terminase large subunit | - |
| ETT70_RS05405 (ETT70_05395) | - | 1027802..1028251 (-) | 450 | WP_281726933.1 | hypothetical protein | - |
| ETT70_RS05410 (ETT70_05400) | - | 1028301..1028678 (-) | 378 | WP_032459833.1 | ASCH domain-containing protein | - |
| ETT70_RS05415 (ETT70_05405) | - | 1028739..1029215 (-) | 477 | WP_186787913.1 | GNAT family N-acetyltransferase | - |
| ETT70_RS05420 (ETT70_05410) | - | 1029131..1029808 (-) | 678 | WP_002986850.1 | ABC transporter ATP-binding protein | - |
| ETT70_RS05425 (ETT70_05415) | - | 1029787..1030305 (-) | 519 | WP_136026505.1 | ParB N-terminal domain-containing protein | - |
| ETT70_RS05430 (ETT70_05420) | - | 1030386..1030643 (+) | 258 | WP_011054748.1 | hypothetical protein | - |
| ETT70_RS05445 (ETT70_05435) | - | 1031218..1031655 (-) | 438 | WP_021340586.1 | DUF1492 domain-containing protein | - |
| ETT70_RS05450 (ETT70_05440) | - | 1032020..1032313 (-) | 294 | WP_032460172.1 | hypothetical protein | - |
| ETT70_RS05455 (ETT70_05445) | - | 1032361..1033125 (-) | 765 | WP_032463361.1 | site-specific DNA-methyltransferase | - |
| ETT70_RS05460 (ETT70_05450) | - | 1033115..1033201 (-) | 87 | Protein_1008 | SAM-dependent methyltransferase | - |
| ETT70_RS05465 (ETT70_05455) | - | 1033364..1033633 (-) | 270 | WP_032463364.1 | hypothetical protein | - |
| ETT70_RS09395 (ETT70_05460) | - | 1033638..1033823 (-) | 186 | WP_011017985.1 | hypothetical protein | - |
| ETT70_RS05475 (ETT70_05465) | - | 1033810..1034322 (-) | 513 | WP_032463367.1 | phage protein | - |
| ETT70_RS05480 (ETT70_05470) | - | 1034319..1034660 (-) | 342 | WP_011888757.1 | hypothetical protein | - |
| ETT70_RS05485 (ETT70_05475) | - | 1034857..1035885 (-) | 1029 | WP_011888756.1 | DUF1351 domain-containing protein | - |
| ETT70_RS05490 (ETT70_05480) | bet | 1035895..1036686 (-) | 792 | WP_002990071.1 | phage recombination protein Bet | - |
| ETT70_RS05495 (ETT70_05485) | - | 1036689..1037018 (-) | 330 | WP_085613678.1 | hypothetical protein | - |
| ETT70_RS05500 (ETT70_05490) | - | 1037040..1037294 (-) | 255 | WP_136059189.1 | hypothetical protein | - |
| ETT70_RS05505 (ETT70_05495) | - | 1037281..1037565 (-) | 285 | WP_227878030.1 | hypothetical protein | - |
| ETT70_RS05510 (ETT70_05500) | - | 1037769..1038551 (-) | 783 | WP_136059187.1 | ATP-binding protein | - |
| ETT70_RS05515 (ETT70_05505) | - | 1038538..1039299 (-) | 762 | WP_014635613.1 | DnaD domain protein | - |
| ETT70_RS05520 (ETT70_05510) | - | 1039393..1039530 (-) | 138 | WP_011017881.1 | hypothetical protein | - |
| ETT70_RS05525 (ETT70_05515) | - | 1039527..1039823 (-) | 297 | WP_002984306.1 | MerR family transcriptional regulator | - |
| ETT70_RS09495 (ETT70_05520) | - | 1039902..1039985 (-) | 84 | Protein_1022 | XRE family transcriptional regulator | - |
| ETT70_RS05535 (ETT70_05525) | - | 1040064..1040288 (+) | 225 | WP_136059186.1 | hypothetical protein | - |
| ETT70_RS05540 (ETT70_05530) | - | 1040457..1040657 (-) | 201 | WP_038433319.1 | helix-turn-helix domain-containing protein | - |
| ETT70_RS05545 (ETT70_05535) | - | 1040731..1041213 (+) | 483 | WP_023605145.1 | hypothetical protein | - |
| ETT70_RS09235 | - | 1041210..1041356 (-) | 147 | WP_168645150.1 | hypothetical protein | - |
| ETT70_RS05550 (ETT70_05540) | - | 1041413..1042180 (+) | 768 | WP_136114188.1 | hypothetical protein | - |
| ETT70_RS05555 (ETT70_05545) | - | 1042314..1042472 (-) | 159 | WP_085613682.1 | hypothetical protein | - |
| ETT70_RS05560 (ETT70_05550) | - | 1042531..1042746 (+) | 216 | WP_014635530.1 | hypothetical protein | - |
| ETT70_RS09240 | - | 1042732..1042881 (-) | 150 | WP_168391463.1 | hypothetical protein | - |
| ETT70_RS05565 (ETT70_05555) | - | 1043234..1044058 (+) | 825 | WP_136114187.1 | helix-turn-helix transcriptional regulator | - |
| ETT70_RS05570 (ETT70_05560) | - | 1044243..1045196 (+) | 954 | WP_136059184.1 | Abi family protein | - |
| ETT70_RS05575 (ETT70_05565) | - | 1045317..1046405 (+) | 1089 | WP_023079773.1 | site-specific integrase | - |
| ETT70_RS05580 (ETT70_05570) | - | 1046768..1047388 (+) | 621 | WP_002989605.1 | DUF3862 domain-containing protein | - |
Sequence
Protein
Download Length: 47 a.a. Molecular weight: 5410.24 Da Isoelectric Point: 4.0339
>NTDB_id=341119 ETT70_RS05275 WP_136113944.1 1006447..1006590(-) (prx) [Streptococcus pyogenes strain emmNA]
MLTYDEFKQAIDDGYITGDTVMIVRKSGQIFDYVLLGEPVKPWEILT
MLTYDEFKQAIDDGYITGDTVMIVRKSGQIFDYVLLGEPVKPWEILT
Nucleotide
Download Length: 144 bp
>NTDB_id=341119 ETT70_RS05275 WP_136113944.1 1006447..1006590(-) (prx) [Streptococcus pyogenes strain emmNA]
ATGCTAACATACGACGAGTTTAAGCAAGCTATTGATGACGGATATATCACAGGAGACACGGTTATGATCGTGCGCAAGAG
CGGACAGATTTTTGATTATGTGTTGCTTGGTGAGCCTGTGAAACCGTGGGAAATTTTGACTTAA
ATGCTAACATACGACGAGTTTAAGCAAGCTATTGATGACGGATATATCACAGGAGACACGGTTATGATCGTGCGCAAGAG
CGGACAGATTTTTGATTATGTGTTGCTTGGTGAGCCTGTGAAACCGTGGGAAATTTTGACTTAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| prx | Streptococcus pyogenes MGAS315 |
78.723 |
100 |
0.787 |
| prx | Streptococcus pyogenes MGAS315 |
76.596 |
100 |
0.766 |
| prx | Streptococcus pyogenes MGAS8232 |
76.596 |
100 |
0.766 |
| prx | Streptococcus pyogenes MGAS315 |
83.333 |
89.362 |
0.745 |
| prx | Streptococcus pyogenes MGAS315 |
82.927 |
87.234 |
0.723 |
| prx | Streptococcus pyogenes MGAS315 |
73.913 |
97.872 |
0.723 |
| prx | Streptococcus pyogenes MGAS315 |
70.732 |
87.234 |
0.617 |