Detailed information NTG0338144

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: EQH22_RS04400
• Genome accession: NZ_CP035258
• Coordinates: 875006..875656 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387330.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901927
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 870006..880656

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH22_RS04370 (EQH22_04620)	-	870489..870704 (+)	216	WP_001232082.1	YozE family protein	-
EQH22_RS04375 (EQH22_04625)	-	870790..871758 (+)	969	WP_000658183.1	PhoH family protein	-
EQH22_RS04380 (EQH22_04635)	-	871951..872451 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
EQH22_RS04385 (EQH22_04640)	-	872454..872780 (+)	327	Protein_883	TfoX/Sxy family protein	-
EQH22_RS04390	ald	873081..874192 (-)	1112	Protein_884	alanine dehydrogenase	-
EQH22_RS04395 (EQH22_04660)	-	874369..874938 (+)	570	WP_000443899.1	GNAT family N-acetyltransferase	-
EQH22_RS04400 (EQH22_04665)	comEA/celA/cilE	875006..875656 (+)	651	WP_000387330.1	ComEA family DNA-binding protein	Machinery gene
EQH22_RS04405 (EQH22_04670)	comEC/celB	875640..877880 (+)	2241	WP_000942406.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EQH22_RS04410 (EQH22_04675)	-	878059..878247 (+)	189	WP_001810955.1	hypothetical protein	-
EQH22_RS04415 (EQH22_04680)	-	878279..878866 (+)	588	WP_000933550.1	ATP-binding cassette domain-containing protein	-
EQH22_RS04420 (EQH22_04685)	-	878870..880051 (+)	1182	WP_000655933.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23229.65 Da
• Isoelectric Point: 5.5171

>NTDB_id=338144 EQH22_RS04400 WP_000387330.1 875006..875656(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901927]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=338144 EQH22_RS04400 WP_000387330.1 875006..875656(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901927]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae D39	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae R6	100	100	1
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.278	100	0.903
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361