Detailed information NTG0337744

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: EQH29_RS04375
• Genome accession: NZ_CP035251
• Coordinates: 873167..873817 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387331.1
• Uniprot ID: A0A0E7VQD3
• Organism: Streptococcus pneumoniae strain TVO_1901935
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 868167..878817

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH29_RS04345 (EQH29_04630)	-	868650..868865 (+)	216	WP_001232082.1	YozE family protein	-
EQH29_RS04350 (EQH29_04635)	-	868951..869919 (+)	969	WP_000658183.1	PhoH family protein	-
EQH29_RS04355 (EQH29_04645)	-	870112..870612 (+)	501	WP_000566983.1	GNAT family N-acetyltransferase	-
EQH29_RS04360 (EQH29_04650)	-	870615..870941 (+)	327	Protein_872	TfoX/Sxy family protein	-
EQH29_RS04365	ald	871242..872353 (-)	1112	Protein_873	alanine dehydrogenase	-
EQH29_RS04370 (EQH29_04670)	-	872530..873099 (+)	570	WP_000443744.1	GNAT family N-acetyltransferase	-
EQH29_RS04375 (EQH29_04675)	comEA/celA/cilE	873167..873817 (+)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
EQH29_RS04380 (EQH29_04680)	comEC/celB	873801..876041 (+)	2241	WP_000942387.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EQH29_RS04385 (EQH29_04685)	-	876183..876407 (+)	225	WP_001813351.1	hypothetical protein	-
EQH29_RS04390 (EQH29_04690)	-	876439..877026 (+)	588	WP_000945253.1	ATP-binding cassette domain-containing protein	-
EQH29_RS04395 (EQH29_04695)	-	877030..878211 (+)	1182	WP_000655954.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23203.57 Da
• Isoelectric Point: 5.5171

>NTDB_id=337744 EQH29_RS04375 WP_000387331.1 873167..873817(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901935]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=337744 EQH29_RS04375 WP_000387331.1 873167..873817(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901935]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A0E7VQD3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361