Detailed information NTG0337433

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: EQH34_RS04480
• Genome accession: NZ_CP035246
• Coordinates: 903753..904601 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705301.1
• Uniprot ID: A0A0D6J8J8
• Organism: Streptococcus pneumoniae strain TVO_1901941
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 898753..909601

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH34_RS04465 (EQH34_04760)	-	899109..899468 (-)	360	WP_001237219.1	YbaN family protein	-
EQH34_RS04470 (EQH34_04765)	topA	899574..901661 (-)	2088	WP_000179642.1	type I DNA topoisomerase	-
EQH34_RS04475 (EQH34_04770)	-	901828..902871 (-)	1044	WP_001812883.1	TIGR00341 family protein	-
EQH34_RS10410	-	903448..903570 (+)	123	WP_001814242.1	hypothetical protein	-
EQH34_RS04480 (EQH34_04775)	dprA/cilB/dalA	903753..904601 (-)	849	WP_000705301.1	DNA-processing protein DprA	Machinery gene
EQH34_RS04485 (EQH34_04780)	-	904697..905386 (-)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
EQH34_RS04490 (EQH34_04785)	-	905398..906276 (-)	879	WP_000837619.1	DMT family transporter	-
EQH34_RS04495 (EQH34_04790)	licA	906266..907135 (-)	870	WP_000411207.1	choline kinase LicA	-
EQH34_RS04500 (EQH34_04795)	-	907152..908174 (-)	1023	WP_000609891.1	ribitol-5-phosphate dehydrogenase	-
EQH34_RS04505 (EQH34_04800)	-	908179..908886 (-)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31034.67 Da
• Isoelectric Point: 5.4047

>NTDB_id=337433 EQH34_RS04480 WP_000705301.1 903753..904601(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain TVO_1901941]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLALSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=337433 EQH34_RS04480 WP_000705301.1 903753..904601(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain TVO_1901941]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATCTCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAACAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGCTCTAAGTGAATATGGACCTGGAGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACCTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A0D6J8J8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.645	100	0.996
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.227	100	0.982
dprA/cilB/dalA	Streptococcus mitis SK321	97.518	100	0.975
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.357	99.291	0.55
dprA	Staphylococcus aureus N315	37.456	100	0.376
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362