Detailed information NTG0033220

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: SPP_RS03685
• Genome accession: NC_012467
• Coordinates: 689248..689838 (+)
• Length: 196 a.a.
• NCBI ID: WP_000613476.1
• Uniprot ID: C1CJJ5
• Organism: Streptococcus pneumoniae P1031
• Function: degradation of ComX; degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 684248..694838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPP_RS03655 (SPP_0751)	-	684636..685091 (-)	456	WP_001823744.1	8-oxo-dGTP diphosphatase	-
SPP_RS03660 (SPP_0752)	-	685111..686286 (-)	1176	WP_001846791.1	NAD(P)/FAD-dependent oxidoreductase	-
SPP_RS03665 (SPP_0753)	-	686345..687190 (-)	846	WP_000219939.1	DegV family protein	-
SPP_RS03670 (SPP_0754)	-	687315..687872 (+)	558	WP_000004139.1	TetR/AcrR family transcriptional regulator	-
SPP_RS03675 (SPP_0755)	-	687891..688358 (+)	468	WP_000136976.1	cytidine/deoxycytidylate deaminase family protein	-
SPP_RS03680 (SPP_0756)	upp	688445..689074 (+)	630	WP_001846793.1	uracil phosphoribosyltransferase	-
SPP_RS03685 (SPP_0757)	clpP	689248..689838 (+)	591	WP_000613476.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
SPP_RS03690 (SPP_0758)	-	689917..690165 (+)	249	WP_000462126.1	YlbG family protein	-
SPP_RS03695 (SPP_0759)	-	690266..691426 (+)	1161	WP_000726147.1	ABC transporter substrate-binding protein	-
SPP_RS03700 (SPP_0761)	-	691694..692563 (+)	870	WP_000941426.1	branched-chain amino acid ABC transporter permease	-
SPP_RS03705 (SPP_0762)	-	692567..693523 (+)	957	WP_000662293.1	branched-chain amino acid ABC transporter permease	-
SPP_RS03710 (SPP_0763)	-	693523..694287 (+)	765	WP_001186003.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21367.37 Da
• Isoelectric Point: 4.5912

>NTDB_id=33220 SPP_RS03685 WP_000613476.1 689248..689838(+) (clpP) [Streptococcus pneumoniae P1031]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAHETLEYGFIDEIMANNSLN

Nucleotide

• Length: 591 bp

>NTDB_id=33220 SPP_RS03685 WP_000613476.1 689248..689838(+) (clpP) [Streptococcus pneumoniae P1031]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCATGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: C1CJJ5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pneumoniae Rx1	99.49	100	0.995
clpP	Streptococcus pneumoniae D39	99.49	100	0.995
clpP	Streptococcus pneumoniae R6	99.49	100	0.995
clpP	Streptococcus pneumoniae TIGR4	99.49	100	0.995
clpP	Streptococcus thermophilus LMG 18311	92.308	99.49	0.918
clpP	Streptococcus thermophilus LMD-9	92.308	99.49	0.918
clpP	Streptococcus pyogenes JRS4	90.769	99.49	0.903
clpP	Streptococcus pyogenes MGAS315	90.769	99.49	0.903
clpP	Streptococcus mutans UA159	85.714	100	0.857
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	85.128	99.49	0.847
clpP	Lactococcus lactis subsp. cremoris KW2	84.615	99.49	0.842
clpP	Bacillus subtilis subsp. subtilis str. 168	58.854	97.959	0.577
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	57.513	98.469	0.566