Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EHW89_RS04900 Genome accession   NZ_CP034543
Coordinates   1003288..1003962 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus periodonticum strain KCOM 2412     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 998288..1008962
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EHW89_RS04890 (EHW89_04890) - 1000048..1001496 (+) 1449 WP_126467016.1 alpha-amylase -
  EHW89_RS04895 (EHW89_04895) ciaH 1001952..1003298 (-) 1347 WP_126467018.1 cell wall metabolism sensor histidine kinase WalK Regulator
  EHW89_RS04900 (EHW89_04900) ciaR 1003288..1003962 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  EHW89_RS04905 (EHW89_04905) - 1004223..1004675 (-) 453 WP_126467020.1 hypothetical protein -
  EHW89_RS04910 (EHW89_04910) - 1005000..1005743 (-) 744 WP_126467022.1 alpha/beta fold hydrolase -
  EHW89_RS04920 (EHW89_04920) rplS 1005985..1006332 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  EHW89_RS04925 (EHW89_04925) - 1006484..1007443 (-) 960 WP_021001748.1 ROK family glucokinase -
  EHW89_RS04930 (EHW89_04930) - 1007717..1008502 (+) 786 WP_126467024.1 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=331787 EHW89_RS04900 WP_003024352.1 1003288..1003962(-) (ciaR) [Streptococcus periodonticum strain KCOM 2412]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=331787 EHW89_RS04900 WP_003024352.1 1003288..1003962(-) (ciaR) [Streptococcus periodonticum strain KCOM 2412]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAGTTGGGTGCTGATGATTATTTGACCAAGCCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment