Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EHW89_RS04895 Genome accession   NZ_CP034543
Coordinates   1001952..1003298 (-) Length   448 a.a.
NCBI ID   WP_126467018.1    Uniprot ID   -
Organism   Streptococcus periodonticum strain KCOM 2412     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 996952..1008298
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EHW89_RS04875 (EHW89_04875) rpsT 997386..997637 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  EHW89_RS04880 (EHW89_04880) - 997701..998210 (+) 510 WP_126467012.1 DNA topology modulation protein -
  EHW89_RS04885 (EHW89_04885) - 998258..999871 (-) 1614 WP_126467014.1 M20/M25/M40 family metallo-hydrolase -
  EHW89_RS04890 (EHW89_04890) - 1000048..1001496 (+) 1449 WP_126467016.1 alpha-amylase -
  EHW89_RS04895 (EHW89_04895) ciaH 1001952..1003298 (-) 1347 WP_126467018.1 cell wall metabolism sensor histidine kinase WalK Regulator
  EHW89_RS04900 (EHW89_04900) ciaR 1003288..1003962 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  EHW89_RS04905 (EHW89_04905) - 1004223..1004675 (-) 453 WP_126467020.1 hypothetical protein -
  EHW89_RS04910 (EHW89_04910) - 1005000..1005743 (-) 744 WP_126467022.1 alpha/beta fold hydrolase -
  EHW89_RS04920 (EHW89_04920) rplS 1005985..1006332 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  EHW89_RS04925 (EHW89_04925) - 1006484..1007443 (-) 960 WP_021001748.1 ROK family glucokinase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50958.66 Da        Isoelectric Point: 10.1380

>NTDB_id=331786 EHW89_RS04895 WP_126467018.1 1001952..1003298(-) (ciaH) [Streptococcus periodonticum strain KCOM 2412]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGLEQKSDNGE
PKADTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=331786 EHW89_RS04895 WP_126467018.1 1001952..1003298(-) (ciaH) [Streptococcus periodonticum strain KCOM 2412]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGCTGGAACAGAAGTCAGACAACGGAGAG
CCTAAAGCCGATACGGGTGACAAAGAACTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATCTTATTTGATAA
GAATTACAAGCCTATTATTACCAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAACAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTTGCACGGGTCAGCGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCCGTTTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCTACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTCCGGAACATGAAAATGTTGACGACAAATCTGCTCAATCTAGCACGGCGTGACGATGGGATTAAACCAGAAATTGGTG
ATGTTGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGTGTGATTAAAACAGACAAGACCTTGCTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGACGAAGACGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCAGGGATTAGTACAGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGACAG
ACAGGTGGTTTTGGTTTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCCCTTAAAGGGACCATTACGGTGAAAGATAA
TAAGCCGAAAGGAACCATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.652

100

0.717
  ciaH Streptococcus pneumoniae D39

71.652

100

0.717
  ciaH Streptococcus pneumoniae R6

71.652

100

0.717
  ciaH Streptococcus pneumoniae TIGR4

71.652

100

0.717
  ciaH Streptococcus mutans UA159

56.236

98.438

0.554

Multiple sequence alignment