Detailed information NTG0032914

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: SUB_RS02260
• Genome accession: NC_012004
• Coordinates: 423579..424169 (+)
• Length: 196 a.a.
• NCBI ID: WP_012657964.1
• Uniprot ID: A0A2X4GXW6
• Organism: Streptococcus uberis 0140J
• Function: degradation of ComX; require for competence development (at the early growth phase); repress competence development (at the mid-logarithmic growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 418579..429169

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SUB_RS02245 (SUB0426)	-	419536..421173 (+)	1638	WP_012657961.1	putative polysaccharide biosynthesis protein	-
SUB_RS02250 (SUB0427)	-	421271..422434 (+)	1164	WP_012657962.1	MalY/PatB family protein	-
SUB_RS02255 (SUB0428)	upp	422526..423155 (+)	630	WP_012657963.1	uracil phosphoribosyltransferase	-
SUB_RS02260 (SUB0429)	clpP	423579..424169 (+)	591	WP_012657964.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
SUB_RS02265 (SUB0430)	-	424412..424858 (+)	447	WP_012657965.1	YlbF family regulator	-
SUB_RS02270 (SUB0431)	-	424858..425115 (+)	258	WP_012657966.1	YlbG family protein	-
SUB_RS02275 (SUB0432)	-	425255..426427 (+)	1173	WP_012657967.1	ABC transporter substrate-binding protein	-
SUB_RS02280 (SUB0433)	-	426468..427337 (+)	870	WP_012657968.1	branched-chain amino acid ABC transporter permease	-
SUB_RS02285 (SUB0434)	-	427340..428293 (+)	954	WP_012657969.1	branched-chain amino acid ABC transporter permease	-
SUB_RS02290 (SUB0435)	-	428293..429057 (+)	765	WP_012657970.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21761.03 Da
• Isoelectric Point: 5.0494

>NTDB_id=32914 SUB_RS02260 WP_012657964.1 423579..424169(+) (clpP) [Streptococcus uberis 0140J]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGSGTQQTDMAIVAEQLLKTRKRLEKILSDNSGK
TIKQIHKDAERDYWMDAKETLEYGFIDAIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=32914 SUB_RS02260 WP_012657964.1 423579..424169(+) (clpP) [Streptococcus uberis 0140J]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGGGAACGTTCTTATGATATTTACTCACGTTTACTGAAAGATCGTAT
TATCATGTTAACTGGTCCTGTTGAGGATAATATGGCAAATTCCATCATTGCTCAATTGCTCTTTTTAGATGCACAAGATA
ATACAAAAGATATTTATTTATACGTCAATACGCCTGGTGGTTCTGTTTCAGCTGGACTTGCCATTGTTGATACAATGAAC
TTTATTAAATCTGATGTTCAAACCATTGTTATGGGTATGGCTGCTTCTATGGGTACCATTATTGCCTCATCAGGTACAAA
AGGGAAACGTTTCATGTTACCAAATGCAGAATACCTCATTCACCAACCAATGGGTGGCACAGGAAGTGGCACACAACAAA
CCGATATGGCCATTGTTGCCGAACAACTTTTGAAAACACGTAAACGCCTTGAAAAAATCCTTTCTGATAACTCTGGAAAA
ACCATTAAACAAATTCATAAAGATGCCGAACGTGATTATTGGATGGATGCAAAAGAAACCTTAGAATATGGGTTCATTGA
TGCCATCATGGAGAACAACGAACTAAAATAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A2X4GXW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus mutans UA159	94.898	100	0.949
clpP	Streptococcus pyogenes JRS4	92.347	100	0.923
clpP	Streptococcus pyogenes MGAS315	92.347	100	0.923
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	91.327	100	0.913
clpP	Lactococcus lactis subsp. cremoris KW2	90.816	100	0.908
clpP	Streptococcus thermophilus LMD-9	89.286	100	0.893
clpP	Streptococcus thermophilus LMG 18311	89.286	100	0.893
clpP	Streptococcus pneumoniae Rx1	86.667	99.49	0.862
clpP	Streptococcus pneumoniae D39	86.667	99.49	0.862
clpP	Streptococcus pneumoniae R6	86.667	99.49	0.862
clpP	Streptococcus pneumoniae TIGR4	86.667	99.49	0.862
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	55.959	98.469	0.551
clpP	Bacillus subtilis subsp. subtilis str. 168	55.102	100	0.551