Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EGX70_RS09140 Genome accession   NZ_CP033808
Coordinates   1738762..1739514 (+) Length   250 a.a.
NCBI ID   WP_001019939.1    Uniprot ID   A0A0E1EJS7
Organism   Streptococcus sp. FDAARGOS_522     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1733762..1744514
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGX70_RS09125 (EGX70_09125) - 1735494..1737677 (+) 2184 WP_000795065.1 PTS transporter subunit IIBC -
  EGX70_RS09130 (EGX70_09130) - 1737731..1738546 (+) 816 WP_001029866.1 endonuclease/exonuclease/phosphatase family protein -
  EGX70_RS09140 (EGX70_09140) comE/blpR 1738762..1739514 (+) 753 WP_001019939.1 LytTR family transcriptional regulator DNA-binding domain-containing protein Regulator
  EGX70_RS09145 (EGX70_09145) - 1739511..1740845 (+) 1335 WP_001089364.1 sensor histidine kinase -
  EGX70_RS09150 (EGX70_09150) - 1740934..1741098 (-) 165 Protein_1678 cysteine peptidase family C39 domain-containing protein -
  EGX70_RS09155 (EGX70_09155) - 1741387..1741560 (+) 174 WP_000683599.1 hypothetical protein -
  EGX70_RS09160 (EGX70_09160) - 1741629..1742476 (+) 848 Protein_1680 ABC transporter ATP-binding protein -
  EGX70_RS09165 (EGX70_09165) - 1742482..1743636 (+) 1155 WP_000623425.1 ABC transporter permease subunit -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29465.07 Da        Isoelectric Point: 8.4441

>NTDB_id=325851 EGX70_RS09140 WP_001019939.1 1738762..1739514(+) (comE/blpR) [Streptococcus sp. FDAARGOS_522]
MNIFILEDNFIQQARLERIIEEVKIRRSIHSKMVNTFEKPVQLLESICEKGMHNLYFLDIEIKNDEQRGLEVAKQIRQID
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEAFSRRIEEVLLYANNACSKNLLEDSFYFKSRYSQVQVPFNDILY
IETSLRSHRVVLYTAKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRSNKLIYLKNGSNCLISRNKIKDIMVV
IEENQRGRGI

Nucleotide


Download         Length: 753 bp        

>NTDB_id=325851 EGX70_RS09140 WP_001019939.1 1738762..1739514(+) (comE/blpR) [Streptococcus sp. FDAARGOS_522]
GTGAATATTTTTATTTTAGAGGATAATTTTATTCAACAGGCACGTTTAGAGAGAATAATTGAGGAAGTTAAAATTAGGAG
AAGTATACACAGTAAAATGGTAAATACCTTTGAAAAACCAGTTCAATTATTGGAATCAATCTGTGAAAAAGGTATGCATA
ATTTATATTTCTTAGACATTGAAATAAAAAATGATGAGCAGAGGGGCTTAGAGGTCGCAAAACAAATTAGACAAATTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCGGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGCATTTAGCAGAAGGATTGAAGAAGTTTTACTATATGCTAATAATGCTTGCA
GTAAAAACTTACTAGAAGATTCTTTTTATTTTAAATCACGCTATAGTCAAGTACAAGTACCTTTTAACGATATCCTTTAT
ATAGAAACGTCATTAAGGTCACATAGAGTTGTCCTTTATACTGCAAAAGACAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTGAATATTTTTAAAGTGGATA
GGTCAAATAAACTAATCTATTTAAAAAATGGTTCGAATTGTTTGATTTCTCGTAATAAAATAAAAGATATTATGGTAGTA
ATAGAGGAAAATCAAAGAGGTAGAGGAATATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-238)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E1EJS7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.61

99.6

0.524
  comE/comE1 Streptococcus equinus JB1

42.678

95.6

0.408
  comE Streptococcus pneumoniae D39

38.866

98.8

0.384
  comE Streptococcus pneumoniae R6

38.866

98.8

0.384
  comE Streptococcus pneumoniae TIGR4

38.866

98.8

0.384
  comE Streptococcus mitis SK321

38.866

98.8

0.384
  comE Streptococcus mitis NCTC 12261

38.866

98.8

0.384
  comE Streptococcus pneumoniae Rx1

38.866

98.8

0.384
  comE Streptococcus infantis strain Atu-4

36.8

100

0.368

Multiple sequence alignment