Detailed information NTG0323134

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EB816_RS05080
• Genome accession: NZ_CP033337
• Coordinates: 975226..975900 (-)
• Length: 224 a.a.
• NCBI ID: WP_023612449.1
• Uniprot ID: A0A5S4THL0
• Organism: Streptococcus pyogenes strain TSPY453
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 970226..980900

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB816_RS05055 (EB816_05055)	-	970673..971062 (-)	390	WP_011285547.1	cytidine deaminase	-
EB816_RS05060 (EB816_05060)	-	971715..972308 (-)	594	WP_032465601.1	class I SAM-dependent methyltransferase	-
EB816_RS05065 (EB816_05065)	coaA	972576..973496 (+)	921	WP_010922353.1	type I pantothenate kinase	-
EB816_RS05070 (EB816_05070)	rpsT	973550..973798 (+)	249	WP_164977038.1	30S ribosomal protein S20	-
EB816_RS05075 (EB816_05075)	ciaH	973923..975233 (-)	1311	WP_011054528.1	HAMP domain-containing sensor histidine kinase	Regulator
EB816_RS05080 (EB816_05080)	ciaR	975226..975900 (-)	675	WP_023612449.1	response regulator transcription factor	Regulator
EB816_RS05085 (EB816_05085)	-	976247..978784 (-)	2538	WP_014407610.1	M1 family metallopeptidase	-
EB816_RS05095 (EB816_05095)	phoU	978989..979642 (-)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-
EB816_RS05100 (EB816_05100)	pstB	979710..980468 (-)	759	WP_002993892.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25704.85 Da
• Isoelectric Point: 4.5928

>NTDB_id=323134 EB816_RS05080 WP_023612449.1 975226..975900(-) (ciaR) [Streptococcus pyogenes strain TSPY453]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGEVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide

• Length: 675 bp

>NTDB_id=323134 EB816_RS05080 WP_023612449.1 975226..975900(-) (ciaR) [Streptococcus pyogenes strain TSPY453]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGGAAGTAGTTGAATTACTTGGTAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A5S4THL0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae D39	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae R6	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae TIGR4	84.685	99.107	0.839
ciaR	Streptococcus mutans UA159	84.685	99.107	0.839
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.667	100	0.388
micA	Streptococcus pneumoniae Cp1015	35.897	100	0.375
vicR	Streptococcus mutans UA159	35.897	100	0.375
covR	Streptococcus salivarius strain HSISS4	36.726	100	0.371