Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   EB818_RS07650 Genome accession   NZ_CP033335
Coordinates   1501426..1501605 (-) Length   59 a.a.
NCBI ID   WP_038432505.1    Uniprot ID   A0A8B6IX98
Organism   Streptococcus pyogenes strain TSPY208     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1500317..1515929 1501426..1501605 within 0


Gene organization within MGE regions


Location: 1500317..1515929
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB818_RS07640 (EB818_07650) - 1500317..1500538 (-) 222 WP_002988211.1 helix-turn-helix transcriptional regulator -
  EB818_RS07645 (EB818_07655) - 1500707..1501081 (+) 375 WP_002988207.1 helix-turn-helix transcriptional regulator -
  EB818_RS07650 (EB818_07660) prx 1501426..1501605 (-) 180 WP_038432505.1 hypothetical protein Regulator
  EB818_RS07655 (EB818_07665) sda3 1501844..1502644 (+) 801 WP_011285611.1 streptodornase Sda3 -
  EB818_RS07665 (EB818_07675) - 1503400..1504266 (-) 867 WP_011888701.1 DUF334 domain-containing protein -
  EB818_RS07670 (EB818_07680) - 1504254..1504778 (-) 525 WP_012560947.1 type II toxin-antitoxin system antitoxin SocA domain-containing protein -
  EB818_RS07675 (EB818_07685) - 1504918..1506126 (-) 1209 WP_012560948.1 glucosaminidase domain-containing protein -
  EB818_RS07680 (EB818_07690) - 1506242..1506427 (-) 186 WP_129322762.1 phage holin -
  EB818_RS07685 (EB818_07695) - 1506445..1506969 (-) 525 Protein_1422 DUF1366 domain-containing protein -
  EB818_RS07690 (EB818_07700) - 1506972..1508951 (-) 1980 WP_129322763.1 gp58-like family protein -
  EB818_RS07695 (EB818_07705) - 1508967..1509971 (-) 1005 WP_012560951.1 hyaluronoglucosaminidase -
  EB818_RS07700 (EB818_07710) - 1509968..1510726 (-) 759 Protein_1425 hypothetical protein -
  EB818_RS07705 (EB818_07715) - 1510727..1511185 (+) 459 Protein_1426 ABC transporter permease -
  EB818_RS07710 (EB818_07720) - 1511182..1511463 (+) 282 Protein_1427 ATP-binding cassette domain-containing protein -
  EB818_RS07715 (EB818_07725) - 1511670..1512200 (+) 531 WP_161237452.1 DUF536 domain-containing protein -
  EB818_RS07720 (EB818_07730) - 1512249..1512836 (+) 588 WP_011018202.1 3'-5' exonuclease -
  EB818_RS07725 (EB818_07735) - 1512989..1513726 (+) 738 WP_002982961.1 MerR family transcriptional regulator -
  EB818_RS07730 (EB818_07740) - 1513783..1514082 (-) 300 WP_002988205.1 YbaB/EbfC family nucleoid-associated protein -
  EB818_RS07740 (EB818_07750) - 1514214..1515929 (-) 1716 Protein_1432 site-specific integrase -

Sequence

Protein


Download         Length: 59 a.a.        Molecular weight: 6792.86 Da        Isoelectric Point: 4.0650

>NTDB_id=323037 EB818_RS07650 WP_038432505.1 1501426..1501605(-) (prx) [Streptococcus pyogenes strain TSPY208]
MLTYDEFKQAIDNGYITADTVMIVRKNGQIFDYVLPGEPVRPWEVMTVEVAGEVLMELR

Nucleotide


Download         Length: 180 bp        

>NTDB_id=323037 EB818_RS07650 WP_038432505.1 1501426..1501605(-) (prx) [Streptococcus pyogenes strain TSPY208]
ATGCTAACATACGACGAGTTTAAACAAGCAATTGACAATGGATATATCACAGCAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTTTTGCCCGGTGAGCCTGTGAGACCGTGGGAGGTTATGACAGTTGAAGTAGCGGGAGAAG
TGCTAATGGAATTGAGGTGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A8B6IX98

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

75.862

98.305

0.746
  prx Streptococcus pyogenes MGAS315

75.862

98.305

0.746
  prx Streptococcus pyogenes MGAS8232

74.138

98.305

0.729
  prx Streptococcus pyogenes MGAS315

74.138

98.305

0.729
  prx Streptococcus pyogenes MGAS315

90.476

71.186

0.644
  prx Streptococcus pyogenes MGAS315

85.366

69.492

0.593
  prx Streptococcus pyogenes MGAS315

75.61

69.492

0.525

Multiple sequence alignment