Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   EB818_RS05080 Genome accession   NZ_CP033335
Coordinates   981204..981392 (-) Length   62 a.a.
NCBI ID   WP_011054546.1    Uniprot ID   A0A5S4TJS4
Organism   Streptococcus pyogenes strain TSPY208     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 973617..993069 981204..981392 within 0


Gene organization within MGE regions


Location: 973617..993069
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB818_RS05045 (EB818_05055) pfkA 973617..974630 (-) 1014 WP_002984444.1 6-phosphofructokinase -
  EB818_RS05050 (EB818_05060) - 974710..977820 (-) 3111 WP_031488246.1 DNA polymerase III subunit alpha -
  EB818_RS05055 (EB818_05065) - 978004..978375 (+) 372 WP_002989617.1 GntR family transcriptional regulator -
  EB818_RS05060 (EB818_05070) - 978375..979073 (+) 699 WP_002984437.1 ABC transporter ATP-binding protein -
  EB818_RS05065 (EB818_05075) - 979083..979868 (+) 786 WP_129322706.1 ABC transporter permease -
  EB818_RS05070 (EB818_05080) - 979999..980613 (-) 615 WP_129322707.1 TVP38/TMEM64 family protein -
  EB818_RS05080 (EB818_05090) prx 981204..981392 (-) 189 WP_011054546.1 hypothetical protein Regulator
  EB818_RS05085 (EB818_05095) spel 981507..982295 (-) 789 WP_021340779.1 streptococcal pyrogenic exotoxin SpeL -
  EB818_RS05090 (EB818_05100) spem 982577..983257 (-) 681 WP_129322708.1 streptococcal pyrogenic exotoxin SpeM -
  EB818_RS05095 (EB818_05105) - 983226..983750 (-) 525 WP_129322709.1 type II toxin-antitoxin system antitoxin SocA domain-containing protein -
  EB818_RS05100 (EB818_05110) - 983889..985097 (-) 1209 WP_012560948.1 glucosaminidase domain-containing protein -
  EB818_RS05105 (EB818_05115) - 985145..985918 (-) 774 Protein_928 terminase large subunit -
  EB818_RS05110 (EB818_05120) - 985933..986400 (-) 468 WP_002985371.1 phage terminase small subunit P27 family -
  EB818_RS05115 (EB818_05125) - 986569..986910 (-) 342 WP_029714359.1 HNH endonuclease signature motif containing protein -
  EB818_RS05125 (EB818_05135) - 987146..987331 (+) 186 WP_001132273.1 type II toxin-antitoxin system HicA family toxin -
  EB818_RS05130 (EB818_05140) - 987383..987760 (+) 378 WP_002987543.1 type II toxin-antitoxin system HicB family antitoxin -
  EB818_RS09150 - 988055..988288 (+) 234 WP_002995461.1 hypothetical protein -
  EB818_RS05140 (EB818_05150) - 988378..989292 (-) 915 WP_011284864.1 hypothetical protein -
  EB818_RS05150 (EB818_05160) - 990064..990504 (-) 441 WP_011017866.1 ArpU family phage packaging/lysis transcriptional regulator -
  EB818_RS05155 (EB818_05165) - 990777..991412 (-) 636 WP_021340848.1 N-6 DNA methylase -
  EB818_RS05160 (EB818_05170) - 991526..992086 (+) 561 Protein_937 site-specific integrase -
  EB818_RS05165 (EB818_05175) - 992449..993069 (+) 621 WP_129322710.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7226.17 Da        Isoelectric Point: 3.9947

>NTDB_id=323024 EB818_RS05080 WP_011054546.1 981204..981392(-) (prx) [Streptococcus pyogenes strain TSPY208]
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGEVVTEEKVEEVMVELDYIK

Nucleotide


Download         Length: 189 bp        

>NTDB_id=323024 EB818_RS05080 WP_011054546.1 981204..981392(-) (prx) [Streptococcus pyogenes strain TSPY208]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGATGACGGATATATCGTAGGAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAGGAAGCGAGAAATGGAGAAGTTGTGACAGAGGAGAAGGTGGAAGAAG
TGATGGTGGAATTAGACTATATCAAATGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TJS4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

100

100

1
  prx Streptococcus pyogenes MGAS315

84.746

95.161

0.806
  prx Streptococcus pyogenes MGAS8232

84.483

93.548

0.79
  prx Streptococcus pyogenes MGAS315

82.759

93.548

0.774
  prx Streptococcus pyogenes MGAS315

77.966

95.161

0.742
  prx Streptococcus pyogenes MGAS315

87.805

66.129

0.581
  prx Streptococcus pyogenes MGAS315

76.19

67.742

0.516

Multiple sequence alignment