Detailed information NTG0317811

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: MGAS28085_RS04600
• Genome accession: NZ_CP032666
• Coordinates: 892814..893488 (+)
• Length: 224 a.a.
• NCBI ID: WP_002984519.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS28085
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 887814..898488

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS28085_RS04580 (MGAS28085_04580)	pstB	888246..889004 (+)	759	WP_002993892.1	phosphate ABC transporter ATP-binding protein PstB	-
MGAS28085_RS04585 (MGAS28085_04585)	phoU	889072..889725 (+)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-
MGAS28085_RS04595 (MGAS28085_04595)	-	889930..892467 (+)	2538	WP_014407610.1	M1 family metallopeptidase	-
MGAS28085_RS04600 (MGAS28085_04600)	ciaR	892814..893488 (+)	675	WP_002984519.1	response regulator transcription factor	Regulator
MGAS28085_RS04605 (MGAS28085_04605)	ciaH	893481..894791 (+)	1311	WP_011054528.1	cell wall metabolism sensor histidine kinase WalK	Regulator
MGAS28085_RS04610 (MGAS28085_04610)	rpsT	894916..895164 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
MGAS28085_RS04615 (MGAS28085_04615)	coaA	895218..896138 (-)	921	WP_010922353.1	type I pantothenate kinase	-
MGAS28085_RS04620 (MGAS28085_04620)	-	896406..896999 (+)	594	WP_021340920.1	class I SAM-dependent methyltransferase	-
MGAS28085_RS04625 (MGAS28085_04625)	-	897650..898039 (+)	390	WP_002984531.1	cytidine deaminase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25703.91 Da
• Isoelectric Point: 4.7287

>NTDB_id=317811 MGAS28085_RS04600 WP_002984519.1 892814..893488(+) (ciaR) [Streptococcus pyogenes strain MGAS28085]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide

• Length: 675 bp

>NTDB_id=317811 MGAS28085_RS04600 WP_002984519.1 892814..893488(+) (ciaR) [Streptococcus pyogenes strain MGAS28085]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	85.135	99.107	0.844
ciaR	Streptococcus pneumoniae D39	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae R6	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae TIGR4	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae Rx1	84.685	99.107	0.839
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.111	100	0.393
vicR	Streptococcus mutans UA159	35.897	100	0.375
micA	Streptococcus pneumoniae Cp1015	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.366