Detailed information NTG0312468

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D1E86_RS10275
• Genome accession: NZ_CP031888
• Coordinates: 2022019..2023062 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CFSAN082782
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2017019..2028062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D1E86_RS10245 (D1E86_10465)	-	2017437..2018693 (-)	1257	WP_001795438.1	aminopeptidase	-
D1E86_RS10250 (D1E86_10470)	-	2018696..2018896 (-)	201	WP_000180461.1	DUF1128 family protein	-
D1E86_RS10255 (D1E86_10475)	-	2019043..2019507 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
D1E86_RS10260 (D1E86_10480)	-	2019514..2019789 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
D1E86_RS10265 (D1E86_10485)	-	2020067..2021284 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
D1E86_RS10270 (D1E86_10490)	vraR	2021400..2022029 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
D1E86_RS10275 (D1E86_10495)	vraS	2022019..2023062 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D1E86_RS10280 (D1E86_10500)	liaF	2023059..2023760 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D1E86_RS10285 (D1E86_10505)	-	2023775..2024161 (-)	387	WP_001110179.1	hypothetical protein	-
D1E86_RS10290 (D1E86_10510)	map	2024378..2025136 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
D1E86_RS10295 (D1E86_10525)	-	2025664..2026650 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
D1E86_RS10300 (D1E86_10535)	-	2027081..2027494 (-)	414	WP_001549145.1	hypothetical protein	-
D1E86_RS10305 (D1E86_10540)	-	2027523..2027633 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=312468 D1E86_RS10275 WP_001017131.1 2022019..2023062(-) (vraS) [Staphylococcus aureus strain CFSAN082782]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=312468 D1E86_RS10275 WP_001017131.1 2022019..2023062(-) (vraS) [Staphylococcus aureus strain CFSAN082782]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1