Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   CH576_RS02980 Genome accession   NZ_CP031691
Coordinates   596832..598175 (+) Length   447 a.a.
NCBI ID   WP_116941727.1    Uniprot ID   -
Organism   Haemophilus influenzae strain P615-8618     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 591832..603175
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CH576_RS02955 (CH576_02955) - 591897..594491 (-) 2595 WP_116941736.1 penicillin-binding protein 1A -
  CH576_RS02960 (CH576_02960) comA 594590..595387 (+) 798 WP_116941735.1 pilus assembly protein PilM Machinery gene
  CH576_RS02965 (CH576_02965) comB 595388..595894 (+) 507 WP_116941733.1 competence protein ComB Machinery gene
  CH576_RS02970 (CH576_02970) comC 595891..596412 (+) 522 WP_116941731.1 competence protein ComC Machinery gene
  CH576_RS02975 (CH576_02975) comD 596409..596822 (+) 414 WP_116941729.1 pilus assembly protein PilP Machinery gene
  CH576_RS02980 (CH576_02980) comE 596832..598175 (+) 1344 WP_116941727.1 type IV pilus secretin PilQ family protein Machinery gene
  CH576_RS02985 (CH576_02985) tnpA 598172..598627 (+) 456 WP_105894588.1 IS200/IS605 family transposase -
  CH576_RS02990 (CH576_02990) - 598916..599602 (+) 687 WP_105894589.1 ComF family protein -
  CH576_RS02995 (CH576_02995) nfuA 599678..600274 (+) 597 WP_050847361.1 Fe-S biogenesis protein NfuA -
  CH576_RS03000 (CH576_03000) nudC 600342..601136 (+) 795 WP_105894590.1 NAD(+) diphosphatase -
  CH576_RS03005 (CH576_03005) - 601172..601762 (+) 591 WP_042594795.1 YjaG family protein -
  CH576_RS03010 (CH576_03010) - 601902..602174 (+) 273 WP_014550417.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 49428.66 Da        Isoelectric Point: 6.9208

>NTDB_id=310233 CH576_RS02980 WP_116941727.1 596832..598175(+) (comE) [Haemophilus influenzae strain P615-8618]
MKKYFLKCGYFLVYFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMDEALESNISLRLDNIDMPRLLQ
IIAKSKHLTLNKDEGIYYLNGGLSGKGQVAGNLATNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPTGSITFDDRSN
LLVIQDDPRSVQNIKKLISEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKKLQ

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=310233 CH576_RS02980 WP_116941727.1 596832..598175(+) (comE) [Haemophilus influenzae strain P615-8618]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTTTAGTGTATTTTTGTTTGCCATTAATCGTTTTTGCTAATCCCAAAAC
TGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCCCAAACATTGGAACAGTTGGCTTTTCAACAAGATG
TGAATTTAGTGATGGATGAAGCATTAGAAAGTAATATTTCATTGAGATTAGATAATATTGATATGCCACGTTTGCTACAA
ATAATCGCAAAAAGTAAGCATCTTACATTGAATAAAGATGAGGGCATTTACTATCTGAATGGAGGGCTATCAGGCAAAGG
GCAAGTTGCAGGAAATCTTGCTACAAATGAACCGCACTTAGTGAGTCATACGGTTAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACCACAGGGAGCGGTTCTTTGCTTTCTCCTACAGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTGGTTATTCAGGATGATCCTCGTTCTGTACAAAATATCAAAAAACTAATTTCTGAAATGGATAAACCTATTGAGCA
GATTGCTATTGAAGCGCGTATTGTGACGATAACAGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACGGAAAATGCAAGACGAGTTGCGGGCAGTCTTGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTCGATTTAGAATT
AAGCGCGTTAGAGCGTGAAAATAATGTGGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTATATTGTGAGCAATACTCGTAACGATACGCAATCAGTGGAATTTCGCGAGGCGGTG
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAGCAAAAAAGTGCGGGGAAAAAGTTACAATGA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

95.955

99.553

0.955
  comE Haemophilus influenzae 86-028NP

95.73

99.553

0.953
  comE Glaesserella parasuis strain SC1401

52.471

95.078

0.499
  pilQ Vibrio campbellii strain DS40M4

43.198

93.736

0.405
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.961

92.17

0.396
  pilQ Vibrio cholerae strain A1552

42.961

92.17

0.396

Multiple sequence alignment