Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   E1A98_RS18735 Genome accession   NZ_CP037857
Coordinates   3843158..3843748 (-) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli BW25113 strain AM187     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 3838158..3848748
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E1A98_RS18720 (E1A98_18740) uhpT 3838798..3840189 (-) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -
  E1A98_RS18725 (E1A98_18745) uhpC 3840327..3841646 (-) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  E1A98_RS18730 (E1A98_18750) uhpB 3841656..3843158 (-) 1503 WP_001295243.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  E1A98_RS18735 (E1A98_18755) letA 3843158..3843748 (-) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  E1A98_RS18740 (E1A98_18760) ilvN 3843824..3844114 (-) 291 WP_001181706.1 acetolactate synthase small subunit -
  E1A98_RS18745 (E1A98_18765) ilvB 3844118..3845806 (-) 1689 WP_000168475.1 acetolactate synthase large subunit -
  E1A98_RS18750 (E1A98_18770) ivbL 3845912..3846010 (-) 99 WP_001300753.1 ilvB operon leader peptide IvbL -
  E1A98_RS18755 (E1A98_18775) tisB 3846575..3846664 (+) 90 WP_001054909.1 type I toxin-antitoxin system toxin TisB -
  E1A98_RS18760 (E1A98_22670) ysdE 3846788..3846862 (-) 75 WP_211180519.1 protein YsdE -
  E1A98_RS18765 (E1A98_18780) emrD 3846944..3848128 (+) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  E1A98_RS18770 (E1A98_18785) yidF 3848136..3848633 (-) 498 WP_000148061.1 radical SAM protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=308541 E1A98_RS18735 WP_000633668.1 3843158..3843748(-) (letA) [Escherichia coli BW25113 strain AM187]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=308541 E1A98_RS18735 WP_000633668.1 3843158..3843748(-) (letA) [Escherichia coli BW25113 strain AM187]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378

Multiple sequence alignment