Detailed information NTG0308117

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: DZ066_RS08180
• Genome accession: NZ_CP031619
• Coordinates: 1582021..1582611 (-)
• Length: 196 a.a.
• NCBI ID: WP_011284532.1
• Uniprot ID: Q48V25
• Organism: Streptococcus pyogenes strain MGAS29284
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1577021..1587611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DZ066_RS08150 (DZ066_08135)	-	1577361..1577753 (-)	393	WP_002985833.1	DUF5684 domain-containing protein	-
DZ066_RS08155 (DZ066_08140)	rsmI	1577780..1578643 (-)	864	WP_002985836.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
DZ066_RS08160 (DZ066_08145)	yabA	1578648..1578971 (-)	324	WP_002985838.1	DNA replication initiation control protein YabA	-
DZ066_RS08165 (DZ066_08150)	-	1579474..1580349 (-)	876	WP_002985844.1	DNA polymerase III subunit delta'	-
DZ066_RS08170 (DZ066_08155)	tmk	1580367..1581002 (-)	636	WP_002990917.1	dTMP kinase	-
DZ066_RS08175 (DZ066_08160)	-	1581251..1581526 (-)	276	WP_011284533.1	YlbG family protein	-
DZ066_RS08180 (DZ066_08165)	clpP	1582021..1582611 (-)	591	WP_011284532.1	ATP-dependent Clp protease proteolytic subunit	Regulator
DZ066_RS08190 (DZ066_08175)	upp	1582835..1583464 (-)	630	WP_002985854.1	uracil phosphoribosyltransferase	-
DZ066_RS08195 (DZ066_08180)	-	1583632..1585266 (-)	1635	WP_011284531.1	polysaccharide biosynthesis protein	-
DZ066_RS08200 (DZ066_08185)	-	1585354..1586799 (+)	1446	WP_011284530.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21678.91 Da
• Isoelectric Point: 5.2834

>NTDB_id=308117 DZ066_RS08180 WP_011284532.1 1582021..1582611(-) (clpP) [Streptococcus pyogenes strain MGAS29284]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLTYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=308117 DZ066_RS08180 WP_011284532.1 1582021..1582611(-) (clpP) [Streptococcus pyogenes strain MGAS29284]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACGAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCACAAAATGCTGGGAAA
ACGATTAAACAAATTCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGACTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: Q48V25

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pyogenes MGAS315	99.49	100	0.995
clpP	Streptococcus pyogenes JRS4	99.49	100	0.995
clpP	Streptococcus mutans UA159	90.816	100	0.908
clpP	Streptococcus pneumoniae Rx1	90.769	99.49	0.903
clpP	Streptococcus pneumoniae D39	90.769	99.49	0.903
clpP	Streptococcus pneumoniae R6	90.769	99.49	0.903
clpP	Streptococcus pneumoniae TIGR4	90.769	99.49	0.903
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	86.224	100	0.862
clpP	Lactococcus lactis subsp. cremoris KW2	85.714	100	0.857
clpP	Bacillus subtilis subsp. subtilis str. 168	57.143	100	0.571
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.995	98.469	0.561