Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   SPCG_RS04840 Genome accession   NC_010582
Coordinates   910822..911472 (+) Length   216 a.a.
NCBI ID   WP_000387344.1    Uniprot ID   A0A0T9GI09
Organism   Streptococcus pneumoniae CGSP14     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 905822..916472
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPCG_RS13015 - 906802..907592 (+) 791 Protein_916 IS5 family transposase -
  SPCG_RS04815 (SPCG_0925) - 907775..908275 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  SPCG_RS04820 (SPCG_0926) - 908278..908604 (+) 327 Protein_918 TfoX/Sxy family protein -
  SPCG_RS12290 (SPCG_0928) ald 908909..910008 (-) 1100 Protein_919 alanine dehydrogenase -
  SPCG_RS04835 (SPCG_0929) - 910185..910754 (+) 570 WP_000443750.1 GNAT family N-acetyltransferase -
  SPCG_RS04840 (SPCG_0930) comEA/celA/cilE 910822..911472 (+) 651 WP_000387344.1 helix-hairpin-helix domain-containing protein Machinery gene
  SPCG_RS04845 (SPCG_0931) comEC/celB 911456..913696 (+) 2241 WP_000942394.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  SPCG_RS04850 (SPCG_0932) - 913875..914063 (+) 189 WP_001808514.1 hypothetical protein -
  SPCG_RS04855 (SPCG_0933) - 914096..914675 (+) 580 Protein_924 ATP-binding cassette domain-containing protein -
  SPCG_RS04860 (SPCG_0934) - 914679..915863 (+) 1185 WP_000655960.1 ABC transporter permease -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23181.48 Da        Isoelectric Point: 6.0746

>NTDB_id=30609 SPCG_RS04840 WP_000387344.1 910822..911472(+) (comEA/celA/cilE) [Streptococcus pneumoniae CGSP14]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDSSTEKEVKKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=30609 SPCG_RS04840 WP_000387344.1 910822..911472(+) (comEA/celA/cilE) [Streptococcus pneumoniae CGSP14]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGAAAAGGAAGTGAAGAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T9GI09

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

100

100

1
  comEA/celA/cilE Streptococcus pneumoniae Rx1

97.222

100

0.972
  comEA/celA/cilE Streptococcus pneumoniae D39

97.222

100

0.972
  comEA/celA/cilE Streptococcus pneumoniae R6

97.222

100

0.972
  comEA/celA/cilE Streptococcus mitis NCTC 12261

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis SK321

93.056

100

0.931
  comEA Lactococcus lactis subsp. cremoris KW2

41.778

100

0.435
  comEA Latilactobacillus sakei subsp. sakei 23K

34.335

100

0.37

Multiple sequence alignment