Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   DV130_RS03185 Genome accession   NZ_CP031248
Coordinates   607755..608405 (-) Length   216 a.a.
NCBI ID   WP_000387331.1    Uniprot ID   A0A0E7VQD3
Organism   Streptococcus pneumoniae strain M26365     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 602755..613405
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV130_RS03165 - 603366..604541 (-) 1176 WP_050072215.1 hypothetical protein -
  DV130_RS03170 - 604545..605132 (-) 588 WP_050072216.1 ABC transporter ATP-binding protein -
  DV130_RS03175 - 605164..605352 (-) 189 WP_001809102.1 hypothetical protein -
  DV130_RS03180 comEC/celB 605531..607771 (-) 2241 WP_044727637.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  DV130_RS03185 comEA/celA/cilE 607755..608405 (-) 651 WP_000387331.1 ComEA family DNA-binding protein Machinery gene
  DV130_RS03190 - 608472..609041 (-) 570 WP_000443745.1 GNAT family N-acetyltransferase -
  DV130_RS12370 ald 609218..610305 (+) 1088 Protein_624 alanine dehydrogenase -
  DV130_RS03210 - 610606..610932 (-) 327 Protein_625 TfoX/Sxy family protein -
  DV130_RS03215 - 610935..611435 (-) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  DV130_RS03225 - 611628..612596 (-) 969 WP_000658183.1 PhoH family protein -
  DV130_RS03230 - 612682..612897 (-) 216 WP_001232082.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23203.57 Da        Isoelectric Point: 5.5171

>NTDB_id=304831 DV130_RS03185 WP_000387331.1 607755..608405(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain M26365]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=304831 DV130_RS03185 WP_000387331.1 607755..608405(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain M26365]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E7VQD3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae D39

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae R6

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.685

100

0.977
  comEA/celA/cilE Streptococcus mitis NCTC 12261

96.296

100

0.963
  comEA/celA/cilE Streptococcus mitis SK321

90.741

100

0.907
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361

Multiple sequence alignment