Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   DV129_RS04280 Genome accession   NZ_CP031247
Coordinates   796768..797358 (-) Length   196 a.a.
NCBI ID   WP_000613476.1    Uniprot ID   C1CJJ5
Organism   Streptococcus pneumoniae strain M23734     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 787813..798717 796768..797358 within 0


Gene organization within MGE regions


Location: 787813..798717
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV129_RS04225 ftsX 787813..788739 (-) 927 WP_000625536.1 permease-like cell division protein FtsX -
  DV129_RS04230 ftsE 788732..789424 (-) 693 WP_000022268.1 cell division ATP-binding protein FtsE -
  DV129_RS04240 - 790645..791301 (-) 657 WP_000268677.1 CBS domain-containing protein -
  DV129_RS04245 - 791609..792319 (-) 711 WP_000062216.1 ABC transporter ATP-binding protein -
  DV129_RS04250 - 792319..793083 (-) 765 WP_001186003.1 ABC transporter ATP-binding protein -
  DV129_RS04255 - 793083..794039 (-) 957 WP_000662293.1 branched-chain amino acid ABC transporter permease -
  DV129_RS04260 - 794043..794912 (-) 870 WP_000941426.1 branched-chain amino acid ABC transporter permease -
  DV129_RS04265 - 795180..796340 (-) 1161 WP_000726147.1 ABC transporter substrate-binding protein -
  DV129_RS04270 - 796441..796689 (-) 249 WP_000462126.1 YlbG family protein -
  DV129_RS04280 clpP 796768..797358 (-) 591 WP_000613476.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  DV129_RS04285 upp 797532..798161 (-) 630 WP_001846793.1 uracil phosphoribosyltransferase -
  DV129_RS04290 - 798250..798717 (-) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21367.37 Da        Isoelectric Point: 4.5912

>NTDB_id=304759 DV129_RS04280 WP_000613476.1 796768..797358(-) (clpP) [Streptococcus pneumoniae strain M23734]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAHETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=304759 DV129_RS04280 WP_000613476.1 796768..797358(-) (clpP) [Streptococcus pneumoniae strain M23734]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCATGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CJJ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

99.49

100

0.995
  clpP Streptococcus pneumoniae D39

99.49

100

0.995
  clpP Streptococcus pneumoniae R6

99.49

100

0.995
  clpP Streptococcus pneumoniae TIGR4

99.49

100

0.995
  clpP Streptococcus thermophilus LMG 18311

92.308

99.49

0.918
  clpP Streptococcus thermophilus LMD-9

92.308

99.49

0.918
  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903
  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903
  clpP Streptococcus mutans UA159

85.714

100

0.857
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847
  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842
  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

57.513

98.469

0.566

Multiple sequence alignment