Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   SPH_RS10770 Genome accession   NC_010380
Coordinates   2021892..2022845 (-) Length   317 a.a.
NCBI ID   WP_000345126.1    Uniprot ID   A0A0F7YBB9
Organism   Streptococcus pneumoniae Hungary19A-6     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2016892..2027845
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPH_RS10745 (SPH_2192) - 2017653..2018276 (-) 624 WP_000932657.1 hypothetical protein -
  SPH_RS10750 (SPH_2193) jag 2018327..2019313 (-) 987 WP_000260027.1 RNA-binding cell elongation regulator Jag/EloR -
  SPH_RS10755 (SPH_2194) - 2019332..2020156 (-) 825 WP_001832473.1 membrane protein insertase YidC -
  SPH_RS10760 (SPH_2195) rnpA 2020131..2020502 (-) 372 WP_000739244.1 ribonuclease P protein component -
  SPH_RS14265 (SPH_2196) - 2020519..2020650 (-) 132 WP_000768904.1 hypothetical protein -
  SPH_RS10765 (SPH_2197) - 2020651..2021841 (-) 1191 WP_000167753.1 acetate kinase -
  SPH_RS10770 (SPH_2198) comYH 2021892..2022845 (-) 954 WP_000345126.1 class I SAM-dependent methyltransferase Machinery gene
  SPH_RS12980 - 2022906..2023500 (-) 595 Protein_2032 methyltransferase domain-containing protein -
  SPH_RS10785 (SPH_2201) comGG/cglG 2023637..2024050 (-) 414 WP_000265625.1 competence type IV pilus minor pilin ComGG Machinery gene
  SPH_RS10790 (SPH_2202) comGF/cglF 2024028..2024489 (-) 462 WP_000250508.1 competence type IV pilus minor pilin ComGF Machinery gene
  SPH_RS10795 (SPH_2203) comGE/cglE 2024452..2024754 (-) 303 WP_191995726.1 competence type IV pilus minor pilin ComGE Machinery gene
  SPH_RS10800 (SPH_2204) comGD/cglD 2024717..2025151 (-) 435 WP_041864711.1 competence type IV pilus minor pilin ComGD Machinery gene
  SPH_RS10805 (SPH_2205) comGC/cglC 2025114..2025437 (-) 324 WP_000738648.1 comG operon protein ComGC Machinery gene
  SPH_RS10810 (SPH_2206) comGB/cglB 2025439..2026455 (-) 1017 WP_079218398.1 competence type IV pilus assembly protein ComGB Machinery gene
  SPH_RS10815 (SPH_2207) comGA/cglA/cilD 2026403..2027344 (-) 942 WP_000249559.1 competence type IV pilus ATPase ComGA Machinery gene
  SPH_RS10820 (SPH_2208) - 2027420..2027785 (-) 366 WP_000286415.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35714.87 Da        Isoelectric Point: 4.2434

>NTDB_id=30041 SPH_RS10770 WP_000345126.1 2021892..2022845(-) (comYH) [Streptococcus pneumoniae Hungary19A-6]
MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQT
EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEVDDLLIDLAASMADVIGLQ
AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ
SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

Nucleotide


Download         Length: 954 bp        

>NTDB_id=30041 SPH_RS10770 WP_000345126.1 2021892..2022845(-) (comYH) [Streptococcus pneumoniae Hungary19A-6]
ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA
CTTTTATGACGCCTTGGTGGAGCAAAACAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAAGACAACAATC
AGGCCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
GAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA
AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTACTTTCTTGACCTCGCTTGATAAAA
AGGTGGATTACTTGGGAATGGAAGTGGATGATTTACTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
GCTGGCTTTGTCCAAGGAGATGCCGTTCGTCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTTGG
CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA
TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA
AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAACCTCTTTGCTAA
TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA
GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(69-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F7YBB9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA140

54.633

98.738

0.539
  comYH Streptococcus mutans UA159

54.313

98.738

0.536

Multiple sequence alignment