Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE/cglE   Type   Machinery gene
Locus tag   SPH_RS10795 Genome accession   NC_010380
Coordinates   2024452..2024754 (-) Length   100 a.a.
NCBI ID   WP_191995726.1    Uniprot ID   -
Organism   Streptococcus pneumoniae Hungary19A-6     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2019452..2029754
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPH_RS10760 (SPH_2195) rnpA 2020131..2020502 (-) 372 WP_000739244.1 ribonuclease P protein component -
  SPH_RS14265 (SPH_2196) - 2020519..2020650 (-) 132 WP_000768904.1 hypothetical protein -
  SPH_RS10765 (SPH_2197) - 2020651..2021841 (-) 1191 WP_000167753.1 acetate kinase -
  SPH_RS10770 (SPH_2198) comYH 2021892..2022845 (-) 954 WP_000345126.1 class I SAM-dependent methyltransferase Machinery gene
  SPH_RS12980 - 2022906..2023500 (-) 595 Protein_2032 methyltransferase domain-containing protein -
  SPH_RS10785 (SPH_2201) comGG/cglG 2023637..2024050 (-) 414 WP_000265625.1 competence type IV pilus minor pilin ComGG Machinery gene
  SPH_RS10790 (SPH_2202) comGF/cglF 2024028..2024489 (-) 462 WP_000250508.1 competence type IV pilus minor pilin ComGF Machinery gene
  SPH_RS10795 (SPH_2203) comGE/cglE 2024452..2024754 (-) 303 WP_191995726.1 competence type IV pilus minor pilin ComGE Machinery gene
  SPH_RS10800 (SPH_2204) comGD/cglD 2024717..2025151 (-) 435 WP_041864711.1 competence type IV pilus minor pilin ComGD Machinery gene
  SPH_RS10805 (SPH_2205) comGC/cglC 2025114..2025437 (-) 324 WP_000738648.1 comG operon protein ComGC Machinery gene
  SPH_RS10810 (SPH_2206) comGB/cglB 2025439..2026455 (-) 1017 WP_079218398.1 competence type IV pilus assembly protein ComGB Machinery gene
  SPH_RS10815 (SPH_2207) comGA/cglA/cilD 2026403..2027344 (-) 942 WP_000249559.1 competence type IV pilus ATPase ComGA Machinery gene
  SPH_RS10820 (SPH_2208) - 2027420..2027785 (-) 366 WP_000286415.1 DUF1033 family protein -
  SPH_RS10825 (SPH_2209) - 2028052..2029307 (+) 1256 WP_088804233.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 100 a.a.        Molecular weight: 11165.14 Da        Isoelectric Point: 9.7273

>NTDB_id=30044 SPH_RS10795 WP_191995726.1 2024452..2024754(-) (comGE/cglE) [Streptococcus pneumoniae Hungary19A-6]
MEKLNALRKQKIRAVILLEAVVALAIFASIATLLLGQIQKNRQEEAKILQKEEVLRVTKMALQTGQNQVNINGVEIQVFS
SEKGLEVYHGSEQLLAIKEP

Nucleotide


Download         Length: 303 bp        

>NTDB_id=30044 SPH_RS10795 WP_191995726.1 2024452..2024754(-) (comGE/cglE) [Streptococcus pneumoniae Hungary19A-6]
ATGGAAAAATTAAACGCATTAAGGAAACAAAAAATTAGGGCAGTGATTTTACTGGAAGCAGTAGTTGCTTTAGCTATCTT
TGCCAGCATTGCGACCCTCCTTTTGGGACAAATTCAAAAGAATAGGCAAGAGGAAGCAAAAATCTTGCAAAAGGAAGAAG
TCTTGAGGGTAACTAAGATGGCCTTGCAGACAGGTCAAAATCAGGTAAACATAAATGGAGTTGAGATTCAGGTGTTTTCT
AGTGAAAAGGGATTGGAGGTCTACCATGGTTCAGAACAGTTGTTGGCTATTAAAGAGCCATAA

Domains

Predicted by InterproScan.

Type II secretory pathway pseudopilin (ComGE)

(16-97)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE/cglE Streptococcus mitis NCTC 12261

98

100

0.98
  comGE/cglE Streptococcus pneumoniae Rx1

98

100

0.98
  comGE/cglE Streptococcus pneumoniae D39

98

100

0.98
  comGE/cglE Streptococcus pneumoniae R6

98

100

0.98
  comGE/cglE Streptococcus pneumoniae TIGR4

98

100

0.98
  comGE/cglE Streptococcus mitis SK321

97

100

0.97
  comYE Streptococcus mutans UA140

42.222

90

0.38
  comYE Streptococcus mutans UA159

42.222

90

0.38

Multiple sequence alignment