Detailed information    

experimental Experimentally validated

Overview

Name   treR   Type   Regulator
Locus tag   SMU_RS09330 Genome accession   NC_004350
Coordinates   1914422..1915135 (+) Length   237 a.a.
NCBI ID   WP_002273717.1    Uniprot ID   Q8KST2
Organism   Streptococcus mutans UA159     
Function   regulate expression of competence genes   
Competence regulation

Function

Deletion of treR caused the downregulation of a number of genes involved in genetic competence and bacteriocin production, supporting the results of a recent study linking trehalose and the S. mutans competence pathways.


Genomic Context

Location: 1909422..1920135
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMU_RS10090 - 1910203..1910541 (-) 339 Protein_1810 lipase -
  SMU_RS09320 (SMU.2037) treC 1910627..1912255 (-) 1629 WP_002262351.1 alpha,alpha-phosphotrehalase -
  SMU_RS09325 (SMU.2038) treP 1912281..1914248 (-) 1968 WP_002262352.1 PTS system trehalose-specific EIIBC component -
  SMU_RS09330 (SMU.2040) treR 1914422..1915135 (+) 714 WP_002273717.1 trehalose operon repressor Regulator
  SMU_RS09335 (SMU.2042) dexA 1915481..1918033 (-) 2553 WP_011074684.1 dextranase DexA -
  SMU_RS09340 (SMU.2043c) dtd 1918518..1918964 (-) 447 WP_002262355.1 D-aminoacyl-tRNA deacylase -

Sequence

Protein


Download         Length: 237 a.a.        Molecular weight: 27781.09 Da        Isoelectric Point: 9.7425

>NTDB_id=440 SMU_RS09330 WP_002273717.1 1914422..1915135(+) (treR) [Streptococcus mutans UA159]
MKKYEIIFKKLEEDILKGHYQMGDYLPPEMELSQTYASSRDTVRKALQLLTKAGFIKTVQGRGSQIIKRERINFPVSQLT
SYQELVKQLQMNVKTNVIAIDKLIVDEKLTKLTGFENKGLVWRITRQRVIDGVASILDTDYLDKALIPHMTREIAEHSIY
DYLENQLKLDIAYAQKIITIDQVSQKDKILLDLDSENHVVSVKSKVYLSNQQQFQFTESRHKLEKFRFVDFARRHRD

Nucleotide


Download         Length: 714 bp        

>NTDB_id=440 SMU_RS09330 WP_002273717.1 1914422..1915135(+) (treR) [Streptococcus mutans UA159]
ATGAAAAAATATGAAATTATTTTTAAAAAACTAGAAGAAGATATTCTCAAAGGACACTATCAAATGGGTGACTATCTTCC
CCCTGAAATGGAACTTAGCCAGACCTATGCCAGCAGCCGAGATACTGTTAGAAAGGCTTTACAGCTCTTGACTAAGGCAG
GTTTTATTAAAACAGTACAGGGAAGGGGATCCCAAATTATCAAGCGTGAGCGCATTAACTTTCCTGTTTCTCAACTAACC
AGCTATCAAGAATTGGTTAAACAATTGCAGATGAATGTCAAGACAAATGTTATTGCTATTGATAAACTGATTGTTGATGA
GAAACTCACCAAACTAACCGGTTTTGAAAATAAAGGTCTTGTCTGGCGCATCACAAGACAGCGCGTCATAGACGGCGTTG
CTTCCATTTTAGATACGGATTATTTGGATAAAGCATTGATTCCTCATATGACCAGAGAAATCGCTGAACATTCTATCTAT
GATTATCTTGAAAATCAACTTAAGCTGGACATTGCCTATGCTCAAAAGATTATTACCATAGATCAAGTATCGCAAAAAGA
TAAAATTTTGCTTGATTTGGATTCTGAAAATCATGTCGTTTCGGTTAAATCTAAAGTTTATCTCAGTAATCAGCAGCAAT
TTCAATTCACTGAAAGCCGGCACAAACTGGAAAAGTTCCGTTTTGTTGACTTTGCCAGACGGCATCGTGATTAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, gntR family (GntR)

(4-65)

UTRA domain (UTRA)

(90-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8KST2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] J L Baker et al. (2018) Characterization of the Trehalose Utilization Operon in Streptococcus mutans Reveals that the TreR Transcriptional Regulator Is Involved in Stress Response Pathways and Toxin Production. Journal of Bacteriology 200(12):e00057-18. [PMID: 29632089]