Detailed information NTG0300408

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DQ228_RS01325
• Genome accession: NZ_CP030250
• Coordinates: 244944..245843 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain CS20
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 239944..250843

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQ228_RS01305	trkA	241080..242429 (-)	1350	WP_014607951.1	Trk system potassium transporter TrkA	-
DQ228_RS01310	-	242718..243227 (+)	510	WP_014607952.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
DQ228_RS01315	-	243539..244096 (+)	558	WP_002949523.1	ECF transporter S component	-
DQ228_RS01320	-	244099..244749 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
DQ228_RS01325	comR	244944..245843 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
DQ228_RS01330	-	246081..246512 (+)	432	Protein_236	cysteine peptidase family C39 domain-containing protein	-
DQ228_RS01335	-	246542..247111 (+)	570	Protein_237	ABC transporter transmembrane domain-containing protein	-
DQ228_RS01340	comA	247280..247489 (+)	210	WP_002946147.1	hypothetical protein	Regulator
DQ228_RS01345	-	247544..248112 (+)	569	Protein_239	ATP-binding cassette domain-containing protein	-
DQ228_RS01350	-	248220..248552 (+)	333	WP_237788614.1	DUF805 domain-containing protein	-
DQ228_RS01355	-	248604..248861 (-)	258	WP_237788615.1	hypothetical protein	-
DQ228_RS01360	-	249102..249404 (-)	303	WP_224103194.1	hypothetical protein	-
DQ228_RS01365	-	249628..249999 (-)	372	WP_224103195.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=300408 DQ228_RS01325 WP_014607953.1 244944..245843(+) (comR) [Streptococcus thermophilus strain CS20]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=300408 DQ228_RS01325 WP_014607953.1 244944..245843(+) (comR) [Streptococcus thermophilus strain CS20]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418