Detailed information NTG0299480

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DP112_RS04250
• Genome accession: NZ_CP030125
• Coordinates: 841054..841725 (+)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain HA1003
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 836054..846725

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DP112_RS04220 (DP112_04220)	pstC	836189..837106 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
DP112_RS04225 (DP112_04225)	pstA	837096..837983 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
DP112_RS04230 (DP112_04230)	pstB	838008..838811 (+)	804	WP_114866431.1	phosphate ABC transporter ATP-binding protein PstB	-
DP112_RS04235 (DP112_04235)	pstB	838823..839581 (+)	759	WP_114866432.1	phosphate ABC transporter ATP-binding protein PstB	-
DP112_RS04240 (DP112_04240)	phoU	839610..840266 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
DP112_RS04245 (DP112_04245)	-	840432..840860 (+)	429	WP_114866433.1	hypothetical protein	-
DP112_RS04250 (DP112_04250)	ciaR	841054..841725 (+)	672	WP_024385291.1	response regulator transcription factor	Regulator
DP112_RS04255 (DP112_04255)	ciaH	841718..843097 (+)	1380	WP_105135003.1	HAMP domain-containing sensor histidine kinase	Regulator
DP112_RS04260 (DP112_04260)	-	843198..844427 (+)	1230	WP_105134493.1	transglutaminase domain-containing protein	-
DP112_RS04265 (DP112_04265)	rpsT	844692..844940 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
DP112_RS04270 (DP112_04270)	coaA	844999..845919 (-)	921	WP_002935283.1	type I pantothenate kinase	-
DP112_RS04275 (DP112_04275)	-	846028..846618 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=299480 DP112_RS04250 WP_024385291.1 841054..841725(+) (ciaR) [Streptococcus suis strain HA1003]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=299480 DP112_RS04250 WP_024385291.1 841054..841725(+) (ciaR) [Streptococcus suis strain HA1003]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGTGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCCACAACTGTAAATGGCGAAGAAGTCGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368