Detailed information NTG0298263

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: A7J09_RS07105
• Genome accession: NZ_CP030015
• Coordinates: 1469034..1469705 (-)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain ISU2812
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1464034..1474705

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7J09_RS07090 (A7J09_07230)	-	1464486..1465715 (-)	1230	WP_029178484.1	transglutaminase domain-containing protein	-
A7J09_RS07095 (A7J09_07235)	-	1466055..1467257 (+)	1203	WP_148124345.1	IS110 family transposase	-
A7J09_RS07100 (A7J09_07245)	ciaH	1467662..1469041 (-)	1380	WP_024394629.1	sensor histidine kinase	Regulator
A7J09_RS07105 (A7J09_07250)	ciaR	1469034..1469705 (-)	672	WP_024385291.1	response regulator transcription factor	Regulator
A7J09_RS07110 (A7J09_07255)	-	1469899..1470234 (-)	336	Protein_1372	hypothetical protein	-
A7J09_RS07115 (A7J09_07260)	phoU	1470400..1471056 (-)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
A7J09_RS07120 (A7J09_07265)	pstB	1471085..1471843 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
A7J09_RS07125 (A7J09_07270)	pstB	1471855..1472658 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
A7J09_RS07130 (A7J09_07275)	pstA	1472683..1473570 (-)	888	WP_029178759.1	phosphate ABC transporter permease PstA	-
A7J09_RS07135 (A7J09_07280)	pstC	1473560..1474477 (-)	918	WP_029178760.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=298263 A7J09_RS07105 WP_024385291.1 1469034..1469705(-) (ciaR) [Streptococcus suis strain ISU2812]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=298263 A7J09_RS07105 WP_024385291.1 1469034..1469705(-) (ciaR) [Streptococcus suis strain ISU2812]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368