Detailed information NTG0298262

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: A7J09_RS07100
• Genome accession: NZ_CP030015
• Coordinates: 1467662..1469041 (-)
• Length: 459 a.a.
• NCBI ID: WP_024394629.1
• Uniprot ID: A0A0Z8PNG1
• Organism: Streptococcus suis strain ISU2812
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1466055..1467257	1467662..1469041	flank	405

Gene organization within MGE regions

Location: 1466055..1469041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7J09_RS07095 (A7J09_07235)	-	1466055..1467257 (+)	1203	WP_148124345.1	IS110 family transposase	-
A7J09_RS07100 (A7J09_07245)	ciaH	1467662..1469041 (-)	1380	WP_024394629.1	sensor histidine kinase	Regulator

Sequence

Protein

• Length: 459 a.a.
• Molecular weight: 51923.64 Da
• Isoelectric Point: 6.8882

>NTDB_id=298262 A7J09_RS07100 WP_024394629.1 1467662..1469041(-) (ciaH) [Streptococcus suis strain ISU2812]
MPKRIRKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKKEPALAVGFAIARTYEPNSVFILQD
SPTGEETTSSSSDSMPVPKNQKNTRAGDQLRLGANTHVLLYSKSGEMINPDTFTGLADLSLDKEKLGEIKETTVESSFGM
SEDYRYITIGLATDELGYYSSYDIKYATILVNVSQIKSSIESYEATVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDEDGTIQIAANIKDKLVCFTVIDNGLGISDT
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKNLDGEISVRDNQPKGTIFEVRLPK

Nucleotide

• Length: 1380 bp

>NTDB_id=298262 A7J09_RS07100 WP_024394629.1 1467662..1469041(-) (ciaH) [Streptococcus suis strain ISU2812]
ATGCCTAAGCGAATCAGAAAATTAGTGTATACGGATAAATTTTCCTTCTTTATCCGTTATTTTGCAGTATTTACCCTGAT
TTTTGGCTTGATGACAGCTATCATTTTTCAATTAATGCGTTCAACTATGTACCAAAATTCAGATAACACCTTGAAACGCA
TTAAGAAAGAACCAGCGCTGGCTGTTGGTTTTGCAATCGCAAGAACCTATGAGCCCAATTCTGTATTTATCCTTCAAGAT
AGTCCAACTGGTGAAGAAACTACGAGCTCTAGTTCAGATAGCATGCCTGTTCCTAAAAATCAAAAAAATACTAGAGCTGG
AGATCAGCTGAGATTAGGTGCCAATACTCATGTTTTACTCTATAGTAAAAGTGGAGAGATGATTAATCCAGATACTTTTA
CTGGTTTGGCCGACCTATCATTAGACAAGGAAAAATTGGGTGAAATTAAGGAAACTACGGTTGAATCAAGTTTTGGTATG
TCTGAAGATTATCGCTATATAACGATTGGGCTGGCTACAGATGAACTAGGTTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTGGTGAATGTCAGCCAAATTAAATCTTCCATTGAGAGCTATGAAGCGACAGTTGCTATTGTTATGGTATCAG
CTTGGTTGATTTCTATACTAGCAAGTATTTACCTATCGAATCTTAGCATGCGTCCAATCCTAATTAGTTATCAAAAACAA
AAAGACTTCGTTGAAAATGCTAGTCATGAGTTACGCACACCGTTGGCAGTTCTTCAAAATCGCCTGGAAAGTCTATTTCG
TCATCCCGAGACAACTATTTTGGAAAGTAGTGAAAGCATCGGATCTAGTTTAGAAGAAGTTCGAAATATGCGACTATTGA
CAACAAATTTACTTAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATCGATGTCCAACCCAACTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCCGAAGAAAATGGAAAAACTCTAACAGTTAATAATTTGATTCATCAGCCAAT
TCGAACAGACAAGGTTTTGATTAAACAGTTGCTCACCATTTTGTTTGACAACGCTATGAAGTATACCGATGAAGATGGGA
CAATTCAAATAGCAGCTAATATCAAGGACAAACTAGTTTGTTTTACAGTTATTGACAATGGTTTGGGAATCAGCGATACC
GATAAAAAGAAAATCTTTGATCGCTTTTACCGAGTTGACAAGGCTAGAACACGTCAAAAAGGTGGATTTGGTTTAGGTTT
ATCTTTAGCTCAACAAATTATTAAGAATTTAGATGGTGAGATTTCTGTGAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTACGTTTACCCAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (240-306)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (350-458)

3D structure

• AlphaFold DB: A0A0Z8PNG1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	49.451	99.129	0.49
ciaH	Streptococcus pneumoniae Rx1	49.127	99.782	0.49
ciaH	Streptococcus pneumoniae D39	49.127	99.782	0.49
ciaH	Streptococcus pneumoniae R6	49.127	99.782	0.49
ciaH	Streptococcus pneumoniae TIGR4	49.127	99.782	0.49