Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   EQH26_RS00615 Genome accession   NZ_CP035254
Coordinates   98268..100421 (+) Length   717 a.a.
NCBI ID   WP_000668286.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901932     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 93268..105421
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH26_RS00585 (EQH26_00595) comR 93469..94362 (+) 894 WP_000343891.1 XRE family transcriptional regulator Regulator
  EQH26_RS00590 (EQH26_00600) - 94905..95201 (+) 297 WP_000837726.1 uberolysin/carnocyclin family circular bacteriocin -
  EQH26_RS00595 (EQH26_00605) - 95208..96344 (+) 1137 WP_000698828.1 hypothetical protein -
  EQH26_RS00600 (EQH26_00610) - 96341..96823 (+) 483 WP_001232094.1 stage II sporulation protein M -
  EQH26_RS00605 (EQH26_00615) - 96820..97416 (+) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  EQH26_RS00610 (EQH26_00620) - 97397..97888 (+) 492 WP_000671990.1 hypothetical protein -
  EQH26_RS00615 (EQH26_00625) comA 98268..100421 (+) 2154 WP_000668286.1 peptide cleavage/export ABC transporter ComA Regulator
  EQH26_RS00620 (EQH26_00630) comB 100434..101783 (+) 1350 WP_000801632.1 competence pheromone export protein ComB Regulator
  EQH26_RS00625 (EQH26_00635) purC 101953..102660 (+) 708 WP_000043303.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  EQH26_RS10890 (EQH26_00640) - 102671..102805 (+) 135 WP_000429436.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80396.46 Da        Isoelectric Point: 6.3365

>NTDB_id=296790 EQH26_RS00615 WP_000668286.1 98268..100421(+) (comA) [Streptococcus pneumoniae strain TVO_1901932]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGDIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNILLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=296790 EQH26_RS00615 WP_000668286.1 98268..100421(+) (comA) [Streptococcus pneumoniae strain TVO_1901932]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTGGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGATATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTCG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACTAATCTCTTTTTCATGACTTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATATCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTAGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.442

100

0.994
  comA Streptococcus pneumoniae D39

99.442

100

0.994
  comA Streptococcus pneumoniae R6

99.442

100

0.994
  comA Streptococcus pneumoniae TIGR4

99.303

100

0.993
  comA Streptococcus mitis SK321

98.187

100

0.982
  comA Streptococcus mitis NCTC 12261

98.187

100

0.982
  comA Streptococcus gordonii str. Challis substr. CH1

80.335

100

0.803
  comA/nlmT Streptococcus mutans UA159

64.575

100

0.646

Multiple sequence alignment