Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DEH83_RS08850 Genome accession   NZ_CP029207
Coordinates   1748651..1749325 (+) Length   224 a.a.
NCBI ID   WP_003068917.1    Uniprot ID   F9P6F2
Organism   Streptococcus constellatus strain TCV107     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1743651..1754325
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DEH83_RS08825 (DEH83_08855) - 1745425..1745682 (+) 258 WP_255776635.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
  DEH83_RS08830 (DEH83_08860) - 1745679..1746050 (+) 372 WP_255776636.1 type II toxin-antitoxin system death-on-curing family toxin -
  DEH83_RS08835 (DEH83_08865) - 1746142..1746393 (-) 252 WP_255776637.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  DEH83_RS08840 (DEH83_08870) - 1746856..1747614 (+) 759 WP_255776638.1 alpha/beta hydrolase -
  DEH83_RS08845 (DEH83_08875) - 1747942..1748385 (+) 444 WP_255776639.1 hypothetical protein -
  DEH83_RS08850 (DEH83_08880) ciaR 1748651..1749325 (+) 675 WP_003068917.1 response regulator transcription factor Regulator
  DEH83_RS08855 (DEH83_08885) ciaH 1749315..1750712 (+) 1398 WP_255776640.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DEH83_RS08860 (DEH83_08890) - 1751132..1752580 (-) 1449 WP_049493216.1 alpha-amylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25300.97 Da        Isoelectric Point: 4.2703

>NTDB_id=291215 DEH83_RS08850 WP_003068917.1 1748651..1749325(+) (ciaR) [Streptococcus constellatus strain TCV107]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKGLREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=291215 DEH83_RS08850 WP_003068917.1 1748651..1749325(+) (ciaR) [Streptococcus constellatus strain TCV107]
ATGATTAAGATTCTATTAGTAGAAGATGACCTTGGTTTATCTAACTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGCTTGTACGAAGCTGAAAGTGGTGTGTACGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGATGGTTTTCAAGTATTGAAGGGATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCCGATGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTAACCA
TTAATTTGTCAACGAACACGACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGCTTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAATAATCTTCAAACACTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P6F2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.071

100

0.911
  ciaR Streptococcus pneumoniae D39

91.071

100

0.911
  ciaR Streptococcus pneumoniae R6

91.071

100

0.911
  ciaR Streptococcus pneumoniae TIGR4

91.071

100

0.911
  ciaR Streptococcus mutans UA159

89.238

99.554

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment