Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   DB248_RS06500 Genome accession   NZ_CP028841
Coordinates   1223646..1223828 (-) Length   60 a.a.
NCBI ID   WP_029714291.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain CCUG 4207     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1223646..1257064 1223646..1223828 within 0


Gene organization within MGE regions


Location: 1223646..1257064
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DB248_RS06500 (DB248_06505) prx 1223646..1223828 (-) 183 WP_029714291.1 hypothetical protein Regulator
  DB248_RS06505 (DB248_06510) sda3 1224057..1224857 (+) 801 WP_011285611.1 streptodornase Sda3 -
  DB248_RS06510 (DB248_06515) - 1225128..1225562 (+) 435 WP_011017966.1 hypothetical protein -
  DB248_RS06515 (DB248_06520) - 1225632..1226837 (-) 1206 WP_010922446.1 glucosaminidase domain-containing protein -
  DB248_RS06520 (DB248_06525) - 1226953..1227180 (-) 228 WP_003058873.1 phage holin -
  DB248_RS06525 (DB248_06530) - 1227177..1227452 (-) 276 WP_002987582.1 hypothetical protein -
  DB248_RS06530 (DB248_06535) - 1227462..1228079 (-) 618 WP_010922447.1 DUF1366 domain-containing protein -
  DB248_RS06535 (DB248_06540) - 1228082..1228513 (-) 432 WP_010922448.1 DUF1617 family protein -
  DB248_RS06540 (DB248_06545) - 1228525..1230309 (-) 1785 WP_010922449.1 gp58-like family protein -
  DB248_RS06545 (DB248_06550) - 1230324..1231325 (-) 1002 WP_023079488.1 hyaluronidase HylP -
  DB248_RS06550 (DB248_06555) - 1231325..1233283 (-) 1959 WP_010922451.1 phage tail spike protein -
  DB248_RS06555 (DB248_06560) - 1233280..1233975 (-) 696 WP_010922452.1 hypothetical protein -
  DB248_RS06560 (DB248_06565) - 1233972..1236329 (-) 2358 WP_010922453.1 hypothetical protein -
  DB248_RS06565 (DB248_06570) - 1236329..1236700 (-) 372 WP_010922454.1 DUF5361 domain-containing protein -
  DB248_RS06570 (DB248_06575) - 1236715..1236978 (-) 264 WP_010922455.1 hypothetical protein -
  DB248_RS06575 (DB248_06580) - 1236989..1237582 (-) 594 WP_010922456.1 tail protein -
  DB248_RS06580 (DB248_06585) - 1237594..1237929 (-) 336 WP_000573598.1 hypothetical protein -
  DB248_RS06585 (DB248_06590) - 1237930..1238166 (-) 237 WP_010922457.1 hypothetical protein -
  DB248_RS06590 (DB248_06595) - 1238159..1238497 (-) 339 WP_011285617.1 hypothetical protein -
  DB248_RS06595 (DB248_06600) - 1238457..1238879 (-) 423 WP_010922459.1 phage Gp19/Gp15/Gp42 family protein -
  DB248_RS06600 (DB248_06605) - 1238889..1239089 (-) 201 WP_010922460.1 hypothetical protein -
  DB248_RS06605 (DB248_06610) - 1239089..1240000 (-) 912 WP_010922461.1 phage major capsid protein -
  DB248_RS06610 (DB248_06615) - 1240025..1240486 (-) 462 WP_010922462.1 DUF4355 domain-containing protein -
  DB248_RS06615 (DB248_06620) - 1240567..1241982 (-) 1416 WP_011285619.1 terminase -
  DB248_RS06620 (DB248_06625) - 1242092..1242358 (-) 267 WP_010922464.1 hypothetical protein -
  DB248_RS06625 (DB248_06630) - 1242351..1242530 (-) 180 WP_015055972.1 hypothetical protein -
  DB248_RS06630 (DB248_06635) - 1242580..1242804 (-) 225 WP_010922466.1 hypothetical protein -
  DB248_RS06635 (DB248_06640) - 1242810..1244303 (-) 1494 WP_010922467.1 hypothetical protein -
  DB248_RS06640 (DB248_06645) - 1244296..1245564 (-) 1269 WP_010922468.1 phage portal protein -
  DB248_RS06645 (DB248_06650) - 1245561..1245917 (-) 357 WP_002994106.1 hypothetical protein -
  DB248_RS06650 (DB248_06655) - 1246066..1246410 (-) 345 WP_010922469.1 HNH endonuclease signature motif containing protein -
  DB248_RS06655 (DB248_06660) - 1246519..1246938 (-) 420 WP_010922470.1 DUF1492 domain-containing protein -
  DB248_RS06660 (DB248_06665) - 1247206..1247841 (-) 636 WP_010922070.1 N-6 DNA methylase -
  DB248_RS06665 (DB248_06670) - 1247843..1248112 (-) 270 WP_002988369.1 hypothetical protein -
  DB248_RS06670 (DB248_06675) - 1248196..1248708 (-) 513 WP_002988366.1 hypothetical protein -
  DB248_RS06675 (DB248_06680) - 1248705..1249046 (-) 342 WP_020837403.1 hypothetical protein -
  DB248_RS10145 - 1249224..1249391 (-) 168 WP_011285624.1 hypothetical protein -
  DB248_RS06680 (DB248_06685) - 1249401..1250198 (-) 798 WP_011285625.1 PD-(D/E)XK nuclease-like domain-containing protein -
  DB248_RS06685 (DB248_06690) - 1250195..1251124 (-) 930 WP_011285626.1 recombinase RecT -
  DB248_RS06690 (DB248_06695) - 1251127..1251456 (-) 330 WP_002988359.1 hypothetical protein -
  DB248_RS06695 (DB248_06700) - 1251512..1251718 (-) 207 WP_011017565.1 hypothetical protein -
  DB248_RS06700 (DB248_06705) - 1251727..1251867 (-) 141 WP_011017992.1 hypothetical protein -
  DB248_RS06705 (DB248_06710) - 1251864..1252097 (-) 234 WP_002985387.1 hypothetical protein -
  DB248_RS06710 (DB248_06715) - 1252078..1252464 (-) 387 WP_011017564.1 DnaD domain-containing protein -
  DB248_RS10350 (DB248_06720) - 1252605..1252874 (-) 270 WP_011106700.1 replication protein -
  DB248_RS06720 (DB248_06725) - 1252968..1253153 (-) 186 WP_010922477.1 hypothetical protein -
  DB248_RS06725 (DB248_06730) - 1253155..1253466 (-) 312 WP_010922478.1 excisionase -
  DB248_RS06730 (DB248_06735) - 1253736..1253948 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  DB248_RS06735 (DB248_06740) - 1254149..1254904 (+) 756 WP_010922480.1 XRE family transcriptional regulator -
  DB248_RS06740 (DB248_06745) - 1254916..1255434 (+) 519 WP_010922481.1 HIRAN domain-containing protein -
  DB248_RS06745 (DB248_06750) - 1255558..1256700 (+) 1143 WP_003051793.1 site-specific integrase -
  DB248_RS06750 (DB248_06755) - 1256789..1257064 (-) 276 WP_002983920.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6974.02 Da        Isoelectric Point: 4.7361

>NTDB_id=288034 DB248_RS06500 WP_029714291.1 1223646..1223828(-) (prx) [Streptococcus pyogenes strain CCUG 4207]
MLTYDEFKQAIDRGYITGDTVMIVRKDGQIFDYVLPHEKVKNGEVVTKEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=288034 DB248_RS06500 WP_029714291.1 1223646..1223828(-) (prx) [Streptococcus pyogenes strain CCUG 4207]
ATGCTAACATACGACGAGTTTAAACAAGCGATTGACCGTGGATATATCACAGGAGACACAGTTATGATCGTGCGTAAAGA
CGGACAGATTTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACTAAGGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

95

100

0.95
  prx Streptococcus pyogenes MGAS315

90

100

0.9
  prx Streptococcus pyogenes MGAS315

80

100

0.8
  prx Streptococcus pyogenes MGAS315

71.667

100

0.717
  prx Streptococcus pyogenes MGAS315

86.047

71.667

0.617
  prx Streptococcus pyogenes MGAS315

85.366

68.333

0.583
  prx Streptococcus pyogenes MGAS315

76.19

70

0.533

Multiple sequence alignment