Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   SM12261_RS06285 Genome accession   NZ_CP028414
Coordinates   1207950..1208540 (-) Length   196 a.a.
NCBI ID   WP_000613475.1    Uniprot ID   F9HD24
Organism   Streptococcus mitis NCTC 12261     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1200060..1211444 1207950..1208540 within 0


Gene organization within MGE regions


Location: 1200060..1211444
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS06230 (SM12261_1214) ftsE 1200060..1200752 (-) 693 WP_000022269.1 cell division ATP-binding protein FtsE -
  SM12261_RS06245 (SM12261_1216) - 1201974..1202630 (-) 657 WP_000268667.1 CBS domain-containing protein -
  SM12261_RS06250 (SM12261_1217) - 1202938..1203648 (-) 711 WP_000062200.1 ABC transporter ATP-binding protein -
  SM12261_RS06255 (SM12261_1218) - 1203648..1204412 (-) 765 WP_001185997.1 ABC transporter ATP-binding protein -
  SM12261_RS06260 (SM12261_1219) - 1204412..1205368 (-) 957 WP_000662290.1 branched-chain amino acid ABC transporter permease -
  SM12261_RS06265 (SM12261_1220) - 1205372..1206241 (-) 870 WP_000941427.1 branched-chain amino acid ABC transporter permease -
  SM12261_RS06270 (SM12261_1221) - 1206358..1207518 (-) 1161 WP_000726117.1 ABC transporter substrate-binding protein -
  SM12261_RS06275 (SM12261_1222) - 1207596..1207871 (-) 276 WP_000462122.1 YlbG family protein -
  SM12261_RS06285 (SM12261_1223) clpP 1207950..1208540 (-) 591 WP_000613475.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  SM12261_RS06290 (SM12261_1224) upp 1208713..1209342 (-) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  SM12261_RS06295 (SM12261_1225) - 1209431..1209898 (-) 468 WP_000136976.1 deoxycytidylate deaminase -
  SM12261_RS06300 (SM12261_1226) - 1209917..1210474 (-) 558 WP_000004136.1 TetR/AcrR family transcriptional regulator -
  SM12261_RS06305 (SM12261_1227) - 1210599..1211444 (+) 846 WP_078228468.1 DegV family protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21340.32 Da        Isoelectric Point: 4.4910

>NTDB_id=284647 SM12261_RS06285 WP_000613475.1 1207950..1208540(-) (clpP) [Streptococcus mitis NCTC 12261]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SIEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=284647 SM12261_RS06285 WP_000613475.1 1207950..1208540(-) (clpP) [Streptococcus mitis NCTC 12261]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGCCCAGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTAGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCTGGTGGTTCCGTTTCAGCTGGTTTGGCAATCGTTGATACCATGAAC
TTTATCAAGGCCGATGTCCAAACCATTGTTATGGGAATGGCAGCATCTATGGGGACGGTCATTGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCAGAGTATATGATCCACCAACCAATGGGTGGTACAGGTGGAGGTACTCAGCAAA
CCGATATGGCGATCGCTGCAGAACACTTGCTTAAAACTCGTAATACTTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATCGAAAAAGTCCATGCAGATGCAGAACGAGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATCATGGCCAACAATTCATTGAATTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9HD24

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

99.49

100

0.995
  clpP Streptococcus pneumoniae D39

99.49

100

0.995
  clpP Streptococcus pneumoniae R6

99.49

100

0.995
  clpP Streptococcus pneumoniae TIGR4

99.49

100

0.995
  clpP Streptococcus thermophilus LMG 18311

93.333

99.49

0.929
  clpP Streptococcus thermophilus LMD-9

93.333

99.49

0.929
  clpP Streptococcus pyogenes JRS4

91.282

99.49

0.908
  clpP Streptococcus pyogenes MGAS315

91.282

99.49

0.908
  clpP Streptococcus mutans UA159

86.224

100

0.862
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847
  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842
  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571

Multiple sequence alignment