Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SM12261_RS03925 Genome accession   NZ_CP028414
Coordinates   725377..727635 (-) Length   752 a.a.
NCBI ID   WP_000882498.1    Uniprot ID   -
Organism   Streptococcus mitis NCTC 12261     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 720377..732635
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS03900 (SM12261_0757) - 722175..723431 (-) 1257 WP_000433508.1 ISL3 family transposase -
  SM12261_RS03905 (SM12261_0758) - 723563..724195 (-) 633 WP_000502303.1 GNAT family N-acetyltransferase -
  SM12261_RS03910 (SM12261_0759) - 724331..724630 (-) 300 WP_000767189.1 DUF1827 family protein -
  SM12261_RS03920 (SM12261_0760) - 724795..725247 (-) 453 WP_000013083.1 NUDIX hydrolase -
  SM12261_RS03925 (SM12261_0761) clpE 725377..727635 (-) 2259 WP_000882498.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SM12261_RS03935 (SM12261_0762) - 727866..728096 (-) 231 WP_049515694.1 DUF1797 family protein -
  SM12261_RS03940 (SM12261_0763) - 728287..728970 (+) 684 WP_001011639.1 amino acid ABC transporter permease -
  SM12261_RS03945 (SM12261_0764) - 728970..729704 (+) 735 WP_000140954.1 amino acid ABC transporter ATP-binding protein -
  SM12261_RS03950 (SM12261_0765) - 729882..730739 (+) 858 WP_000192104.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  SM12261_RS03955 (SM12261_0766) - 730877..731698 (+) 822 WP_000601058.1 hypothetical protein -
  SM12261_RS03960 (SM12261_0767) - 731712..732563 (+) 852 WP_001263817.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83742.15 Da        Isoelectric Point: 5.2972

>NTDB_id=284639 SM12261_RS03925 WP_000882498.1 725377..727635(-) (clpE) [Streptococcus mitis NCTC 12261]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGITDLNNRDFDPFGDFFNDLNNFRPSNNTPPTPP
TQSGGGYGGNGGYGSQNRGPAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=284639 SM12261_RS03925 WP_000882498.1 725377..727635(-) (clpE) [Streptococcus mitis NCTC 12261]
ATGCTTTGTCAAAACTGTAAAATCAATGACTCAACGATTCATCTTTATACCAATCTCAATGGAAAGCAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAGACAGATCCTAACAATAGCCTCTTTAAAGGTATTACGGATCTGAACAATC
GTGACTTTGATCCCTTTGGTGATTTCTTCAATGACCTAAACAATTTCAGGCCTTCTAACAATACTCCTCCGACTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAATGGCGGTTATGGTTCCCAAAATCGTGGACCTGCTCAAACTCCTCCACCAAG
CCAAGAAAAAGGCCTACTGGAAGAATTTGGTATCAACGTAACTGAAATTGCCCGTCGTGGAGATATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATAGAAATTCTCAATCGCAGAACCAAGAATAATCCTGTTCTTATCGGTGAACCA
GGTGTCGGAAAAACTGCCGTTGTCGAAGGTCTAGCTCAGAAAATAGTTGATGGAGATGTTCCCCATAAACTACAAGGAAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAGGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTCGGTGCTGGTTCTGCG
GGCGATGGCAATATGGATGCAGGAAATATCCTCAAGCCCGCCCTTGCTCGTGGAGAGCTGCAATTGGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAAGATGCAGCCCTAGAGCGTCGTATGCAACCTGTTAAAGTGGATGAACCAACAG
TGGAGGAAACAATTACTATCCTCAAAGGCATTCAAAAGAAATACGAAGACTACCACCACGTTCAGTATACCGATGCTGCA
ATTGAAGCAGCTGCAACTCTGTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATCGATCAGCGCTTGATTGAGGCTGAAAATC
TTAAATCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCCGCCTACTTCCGTGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAAGATACTCCTATCATTAGTGAGAAAACCATTGAGCACATTATCGAGCAGAAAACCAA
TATTCCTGTTGGTGATTTAAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGACCTCAAGTCTCATGTTATTG
GACAAGATGATGCTGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGTCTCGGTACCCCTAACCGCCCAATC
GGAAGTTTCCTTTTCGTTGGGCCAACTGGAGTCGGTAAGACAGAACTTTCCAAACAATTAGCTATCGAACTCTTTGGTTC
TGCTGACAGCATGATTCGCTTTGATATGAGTGAATATATGGAAAAACACAGTGTGGCGAAATTAGTCGGTGCCCCTCCAG
GTTATGTCGGCTATGACGAGGCTGGGCAATTAACTGAAAAAGTCCGCCGCAATCCCTACTCTCTTATTCTCTTGGATGAA
GTAGAGAAAGCCCATCCAGATGTCATGCATATGTTCCTCCAGGTCTTGGACGATGGTCGTTTAACAGATGGACAAGGACG
TACCGTTAGCTTCAAGGACGCCATCATCATCATGACTTCAAATGCAGGTACAGGTAAGGCAGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAACTCTGTTCTTGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAAGATAACCTCCTTCAGATTGTCGAGCTTATGCTTGCAGATGTTAACAA
ACGTCTTTCTAGCAACAACATTCATTTGGATGTAACCGACAAGGTCAAGGAAAAATTGGTTGACCTTGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGTACTATTCAAGACTATATTGAGGACGCAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGACCTCAAGGCAGTGATGACCAGCAAGGGTAACATTCAAATCAAATCTGCCAAAAAAGCTGAAGTAAAGAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

AAA lid domain (AAA_lid_9)

(293-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.402

99.867

0.983
  clpE Streptococcus pneumoniae D39

98.402

99.867

0.983
  clpE Streptococcus pneumoniae R6

98.402

99.867

0.983
  clpE Streptococcus pneumoniae TIGR4

98.269

99.867

0.981
  clpE Streptococcus mutans UA159

83.333

99.734

0.831
  clpC Lactococcus lactis subsp. cremoris KW2

75.494

100

0.762
  clpC Bacillus subtilis subsp. subtilis str. 168

51.714

89.229

0.461
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.847

83.378

0.399
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment