Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EFD52_RS07720 Genome accession   NZ_CP033606
Coordinates   1583981..1584649 (-) Length   222 a.a.
NCBI ID   WP_021722129.1    Uniprot ID   -
Organism   Lactococcus lactis strain IL6288     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1578981..1589649
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EFD52_RS07705 (EFD52_07705) yidD 1580245..1580511 (-) 267 WP_010906087.1 membrane protein insertion efficiency factor YidD -
  EFD52_RS07710 (EFD52_07710) - 1580628..1582370 (-) 1743 WP_010906088.1 1-deoxy-D-xylulose-5-phosphate synthase -
  EFD52_RS07715 (EFD52_07715) ciaH 1582518..1583888 (-) 1371 WP_010906089.1 HAMP domain-containing sensor histidine kinase Regulator
  EFD52_RS07720 (EFD52_07720) ciaR 1583981..1584649 (-) 669 WP_021722129.1 response regulator transcription factor Regulator
  EFD52_RS07725 (EFD52_07725) - 1584827..1585801 (-) 975 WP_003130365.1 LacI family DNA-binding transcriptional regulator -
  EFD52_RS07730 (EFD52_07730) - 1585954..1588209 (-) 2256 WP_010906090.1 glycoside hydrolase family 65 protein -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25516.42 Da        Isoelectric Point: 4.4864

>NTDB_id=283771 EFD52_RS07720 WP_021722129.1 1583981..1584649(-) (ciaR) [Lactococcus lactis strain IL6288]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=283771 EFD52_RS07720 WP_021722129.1 1583981..1584649(-) (ciaR) [Lactococcus lactis strain IL6288]
ATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTACGATTTCTTAAAATCATTTGCGCAAGT
CAAACAGGTTTATGATGGAGTTGAAGGACTCTATGAGGCAGAATTGGGAATTTATGATTTAATTTTGCTTGATTTAATGC
TTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACGCCAGTCTTAATCATGACTGCT
AAGGAATCTTTGGATGATAAAATGCACGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTAACTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGATTTAGTCGTT
TATTTAATGCAAAATCAAAACGTTATTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGTTATGACAGTGATACAAC
AGTAACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACCT
TGCGAAATGTTGGCTATATCTTGAGATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

74.775

100

0.748
  ciaR Streptococcus pneumoniae D39

74.775

100

0.748
  ciaR Streptococcus pneumoniae R6

74.775

100

0.748
  ciaR Streptococcus pneumoniae TIGR4

74.775

100

0.748
  ciaR Streptococcus mutans UA159

72.973

100

0.73
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.392
  covR Streptococcus salivarius strain HSISS4

37.333

100

0.378
  vicR Streptococcus mutans UA159

34.764

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.483

100

0.36

Multiple sequence alignment