Detailed information NTG0262096

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLG50_RS07590
• Genome accession: NZ_CP025500
• Coordinates: 1579094..1579786 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis subsp. lactis strain G50
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1574094..1584786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLG50_RS07575 (LLG50_07575)	-	1575713..1576054 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
LLG50_RS07580 (LLG50_07580)	-	1576186..1577427 (-)	1242	WP_015426746.1	ammonium transporter	-
LLG50_RS07585 (LLG50_07585)	covS	1577610..1579085 (-)	1476	WP_103054914.1	HAMP domain-containing sensor histidine kinase	Regulator
LLG50_RS07590 (LLG50_07590)	covR	1579094..1579786 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
LLG50_RS07595 (LLG50_07595)	-	1579942..1580472 (-)	531	WP_103054915.1	YceD family protein	-
LLG50_RS07600 (LLG50_07600)	-	1580603..1580848 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LLG50_RS07605 (LLG50_07605)	-	1581004..1581468 (-)	465	WP_017864799.1	hypothetical protein	-
LLG50_RS07610 (LLG50_07610)	-	1581550..1581912 (-)	363	WP_010906050.1	TIGR02328 family protein	-
LLG50_RS07615 (LLG50_07615)	-	1582137..1582931 (-)	795	WP_103054916.1	CHAP domain-containing protein	-
LLG50_RS07620 (LLG50_07620)	-	1582993..1583829 (-)	837	WP_103054917.1	metallophosphoesterase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=262096 LLG50_RS07590 WP_003130756.1 1579094..1579786(-) (covR) [Lactococcus lactis subsp. lactis strain G50]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=262096 LLG50_RS07590 WP_003130756.1 1579094..1579786(-) (covR) [Lactococcus lactis subsp. lactis strain G50]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACAGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361