Detailed information NTG0023924

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: STU_RS14855
• Genome accession: NC_006448
• Coordinates: 1019684..1020391 (-)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus LMG 18311
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1014684..1025391

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STU_RS14835 (stu1154)	yidA	1015036..1015845 (+)	810	WP_011226081.1	sugar-phosphatase	-
STU_RS14840 (stu1155)	-	1015847..1017061 (+)	1215	WP_004197368.1	aminoacyltransferase	-
STU_RS19510	-	1017113..1017473 (-)	361	Protein_989	YbaN family protein	-
STU_RS14845 (stu1158)	vicX	1017533..1018345 (-)	813	WP_041828379.1	MBL fold metallo-hydrolase	Regulator
STU_RS14850 (stu1159)	vicK	1018351..1019691 (-)	1341	WP_011226083.1	cell wall metabolism sensor histidine kinase VicK	Regulator
STU_RS14855 (stu1160)	vicR	1019684..1020391 (-)	708	WP_011226084.1	response regulator YycF	Regulator
STU_RS14860 (stu1161)	-	1020918..1021685 (+)	768	WP_011226085.1	amino acid ABC transporter ATP-binding protein	-
STU_RS14865 (stu1162)	-	1021697..1022530 (+)	834	WP_011226086.1	transporter substrate-binding domain-containing protein	-
STU_RS14870 (stu1163)	-	1022548..1023246 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
STU_RS14875 (stu1164)	-	1023258..1023908 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
STU_RS14880 (stu1165)	endA	1023979..1024860 (-)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
STU_RS14885 (stu1166)	-	1024922..1025110 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=23924 STU_RS14855 WP_011226084.1 1019684..1020391(-) (vicR) [Streptococcus thermophilus LMG 18311]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=23924 STU_RS14855 WP_011226084.1 1019684..1020391(-) (vicR) [Streptococcus thermophilus LMG 18311]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387